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- 4Gänzle, Michael G.
- 4Willing, Benjamin P.
- 3Chakrabarti, Subhadeep
- 3Field, Catherine J.
- 3Plaizier, Jan C.
- 50Graduate and Postdoctoral Studies (GPS), Faculty of
- 50Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 23Agricultural, Food and Nutritional Science, Department of
- 23Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 3Medicine and Dentistry, Faculty of
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Novel Treatments for Intestinal Failure Explored in Neonatal Piglets with Short Bowel Syndrome: Focusing on the Microbiome, Sepsis and Trophic Factors
DownloadSpring 2024
Short bowel syndrome (SBS) is the leading cause of intestinal failure (IF) in infants, and occurs when there is a significant loss of intestine due to acquired or congenital reasons, leading to infants being unable to absorb sufficient nutrients for survival and growth. SBS traditionally had a...
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2015
Bell, R.C., Mostyn, A., Astbury, S., Symonds, M.E.
Adequate adaptation of the gastrointestinal (GI) tract is important during pregnancy to ensure that the increased metabolic demands by the developing fetus are met. These include changes in surface area mediated by villus hypertrophy and enhanced functional capacity of individual nutrient...
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Fall 2023
The overarching idea of this thesis stemmed from previous work in our lab, where it was noticed that females and males exhibited different disease trajectories in a model of Multiple Sclerosis. Combined with our observation of different outcome metrics for peripheral nociception suggested that...
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Pathologic Evaluation of Type 2 PorcineReproductive and Respiratory SyndromeVirus Infection at the Maternal-FetalInterface of Late Gestation Pregnant Gilts
Download2016-03-10
Novakovic, Predrag, Harding, John C. S., Al-Dissi, Ahmad, Ladinig, Andrea, Detmer, Susan E.
The pathogenesis of fetal death caused by porcine reproductive and respiratory syndromevirus (PRRSV) remains unclear. The objective of this study was to improve our understand-ing of the pathogenesis by assessing potential relationships between specific histopatho-logical lesions and PRRSV RNA...
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Spring 2017
Ruminants have the capacity to utilize fibrous plant materials as substrates to provide energy for maintenance and growth. However, digestion of poor quality forage is incomplete in ruminants and varies among individual animals. Consequently, two studies were conducted in an attempt to elucidate...
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Profiling the Bacterial and Fungal Gut Microbiome of Children with and without Prader-Willi Syndrome (PWS)
DownloadFall 2020
Obesity is a complex multifactorial disease that has a large array of direct (e.g. altered metabolic and inflammatory profile) and indirect (e.g. mental health concerns etc.) consequences on health and is associated with increased morbidity and mortality. Prader-Willi Syndrome (PWS) is the most...
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Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate
Download2015
Zhao, Yuan Y., McMullen,Todd P. W. , Brindley, David N., Curtis, Jonathan M., Benesch, Matthew G. K.
Autotaxin (ATX) is a secreted enzyme, which produces extracellular lysophosphatidate (LPA) from lysophosphatidylcholine (LPC). LPA activates six G protein-coupled receptors and this is essential for vasculogenesis during embryonic development. ATX is also involved in wound healing and...
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Regulation of digestive tract and progenitor cell homeostasis by intestinal bacteria in Drosophila melanogaster
DownloadFall 2020
The digestive tract facilitates nutrient uptake in the presence of a heterogenous cohort of symbiotic microbes. These microbes along with their collective genetic material form the intestinal microbiome and contribute to animal phenotypes. Similar to mammals, the microbiome of insects forms a...
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Revisiting the antifibrinolytic effect of carboxypeptidase N: novel structure and regulation
DownloadFall 2010
Carboxypeptidase N (CPN) is a plasma carboxypeptidase that was discovered in the 1960s as a regulator of inflammation and vascular tone. Through the removal of carboxy-terminal basic residues, CPN alters the activity or binding specificity of inflammatory mediators and vasoactive peptides. CPN...
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Role of Cytochrome P450 1B1 in Inflammation-induced Cardiac Hypertrophy
2023-05-17
ElKhatib, Mohammed, El-Kadi, Ayman
A great deal of research has demonstrated the involvement of cytochrome P450 (CYPs) enzymes and its metabolism of arachidonic acid (AA) in the modulation of cardiac hypertrophy (CH) pathogenesis. Multiple studies demonstrated that inflammation is a major contributor to CH and is known to...