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- 16Curtis, Jonathan M.
- 4Brindley, David N.
- 4Field, Catherine J.
- 3Tang, Xiaoyun
- 3Zhao, Yuan Y.
- 2Benesch, Matthew G. K.
A flow-through enzymatic microreactor for the rapid conversion of triacylglycerols into fatty acid ethyl ester and fatty acid methyl ester derivatives for GC analysisDownload
A flow-through enzymatic microreactor for the rapid conversion of triacylglycerols (TAG) into fatty acid ethyl ester (FAEE) or fatty acid methyl ester (FAME) derivatives was developed. The microreactor was a porous silica monolith fabricated within a 320 μm ID fused silica capillary with lipase...
Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimersDownload
Anti-oxidant capacity is crucial defence against environmental or endogenous oxidative stress. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that plays a key defensive role against oxidative and cytotoxic stress and cellular senescence. However, Nrf2...
Changes in the triacylglycerol content of flaxseeds during development using liquid chromatography-atmospheric pressure photoionization-mass spectrometry (LC-APPI-MS)Download
Changes in the composition of triacylglycerols (TAGs) of three varieties of flaxseeds (H52, O116 and P129) during development were investigated using non-aqueous reversed phase liquid chromatography coupled to atmospheric pressure photoionization-mass spectrometry (LC-APPI-MS). 17 species of...
Characterization of α-Galactooligosaccharides formed via Heterologous Expression of α- 2 Galactosidases from Lactobacillus reuteri in Lactococcus lactisDownload
α-Galacto-oligosaccharides (α-GOS) are produced by transgalactosylation reactions of α-galactosidase (α-Gal) or by conversion of raffinose family oligosaccharides by levansucrase. Similarly to β-GOS, α-GOS have the potential to mimic glycan receptors on eukaryotic cells and act as molecular...
Choline demands during lactation are high; however, detailed knowledge is lacking regarding the optimal dietary intake during this critical period. The present study was designed to determine the effects of varying intakes of choline on maternal immune function during lactation. Primiparous...
Estimation of choline intake from 24 h dietary intake recalls and contribution of egg and milk consumption to intake among pregnant and lactating women in AlbertaDownload
Despite recommendations for higher choline intakes during pregnancy and lactation, there is limited research regarding maternal intake during these important periods. In the present study, we estimated dietary choline intake during pregnancy and lactation in a population of Albertan women and the...
Fungal spoilage of bread remains an unsolved issue in bread making. This work aims to identify alternative strategies to conventional preservatives in order to prevent or delay fungal spoilage of bread. The minimum inhibitory concentration (MIC) of bacterial metabolites and chemical preservatives...
Spontaneous and collision-induced dissociation processes of C02+ ions, formed by electron impact, have been studied in a double-focusing mass spectrometer using techniques of ion kinetic energy spectroscopy. The predissociation process, responsible for unimolecular dissociation of C02+ on the...
Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in miceDownload
Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling. LPP1 expression is low in many cancer cells and tumors compared with normal tissues. It was hypothesized from studies with cultured cells that increasing LPP1 activity would decrease...
Oxidative stress mediates estrogen receptor independent killing and contributes to tamoxifen resistanceDownload
Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...