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- 3Finlay, B. Brett
- 3Gänzle, Michael G.
- 3Willing, Benjamin P.
- 2Antunes, L. Caetano M.
- 2Dieleman, Levinus A.
- 2Gill, Navkiran
- 10Agricultural, Food and Nutritional Science, Department of
- 10Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 3Graduate Studies and Research, Faculty of
- 3Graduate Studies and Research, Faculty of/Theses and Dissertations
- 2Agricultural, Life, and Environmental Sciences, Faculty of
- 2Agricultural, Life, and Environmental Sciences, Faculty of/Journal Articles (Agricultural, Life, & Environmental Sciences)
Host resistance to bacterial infections is thought to be dictated by host genetic factors. Infections by the natural murine enteric pathogen Citrobacter rodentium (used as a model of human enteropathogenic and enterohaemorrhagic E. coli infections) vary between mice strains, from mild...
Campylobacter jejuni colonization is associated with a dysbiosis in the cecal microbiota of mice in the absence of prominent inflammationDownload
Background Campylobacter jejuni causes enterocolitis in humans, but does not incite disease in asymptomatic carrier animals. To survive in the intestine, C. jejuni must successfully compete with the microbiota and overcome the host immune defense. Campylobacter jejuni colonization success varies...
Cerebrospinal fluid in a small cohort of patients with multiple sclerosis was generally free of microbial DNADownload
Multiple sclerosis (MS) is a common cause of non-traumatic neurologic disability with high incidence in many developed countries. Although the etiology of the disease remains elusive, it is thought to entail genetic and environmental causes, and microbial pathogens have also been envisioned as...
Chemically defined diet alters the protective properties of fructo-oligosaccharides and isomalto-oligosaccharides in HLA-B27 transgenic ratsDownload
Non-digestible oligosaccharides (NDO) were shown to reduce inflammation in experimental colitis, but it remains unclear whether microbiota changes mediate their colitis-modulating effects. This study assessed intestinal microbiota and intestinal inflammation after feeding chemically defined...
Development of ruminal and fecal microbiomes are affected by weaning but not weaning strategy in dairy calvesDownload
The nature of weaning, considered the most stressful and significant transition experienced by dairy calves, influences the ability of a calf to adapt to the dramatic dietary shift, and thus, can influence the severity of production losses through the weaning transition. However, the effects of...
Diet and environment shape fecal bacterial microbiota composition and enteric pathogen load of grizzly bearsDownload
Background Diet and environment impact the composition of mammalian intestinal microbiota; dietary or health disturbances trigger alterations in intestinal microbiota composition and render the host susceptible to enteric pathogens. To date no long term monitoring data exist on the fecal...
Initial gut microbial composition as a key factor driving host response to antibiotic treatment, as exemplified by the presence or absence of commensal Escherichia coliDownload
Antibiotics are important for treating bacterial infection; however, efficacies and side effects of antibiotics vary in medicine and experimental models. A few studies have correlated microbiota composition variations with health outcomes in response to antibiotics; however, no study has...
Intestinal microbiota mediate toxicity of irinotecan (CPT-11) cancer therapies and cause systemic infection after CPT-11-induced loss of barrier function. The intestinal microbiota and their functions are thus potential targets for treatment to mitigate CPT-11 toxicity. However, microbiota...
Lactobacillus reuteri maintains a functional mucosal barrier during DSS treatment despite mucus layer dysfunctionDownload
Treatment with the probiotic bacterium Lactobacillus reuteri has been shown to prevent dextran sodium sulfate (DSS)-induced colitis in rats. This is partly due to reduced P-selectin-dependent leukocyte- and platelet-endothelial cell interactions, however, the mechanism behind this protective...
Neonates with intestinal failure (IF), who must rely on parenteral nutrition (PN) for growth and maintenance of health, are at risk for intestinal failure-associated liver disease (IFALD). In neonates, short bowel syndrome (SBS) as a result of intestinal resection is the most common cause of IF....