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Skip to Search Results- 2Benesch, Matthew G. K.
- 2Brindley, David N.
- 2Curtis, Jonathan M.
- 2Zhao, Yuan Y.
- 1Dewald, Jay
- 1McMullen, Todd P. W.
- 1Autotaxin
- 1Autotaxin Inhibition
- 1Breast Cancer
- 1Cell Migration
- 1Cytokines
- 1Epidermal Growth Factor Receptor
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Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in mice
Download2014
Dewald, Jay, Santos, Webster L., Patwardhan, Neeraj, Zhao, Yuan Y., McMullen, Todd P. W., Curtis, Jonathan M., Brindley, David N., Tang, Xiaoyun, Benesch, Matthew G. K.
Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling. LPP1 expression is low in many cancer cells and tumors compared with normal tissues. It was hypothesized from studies with cultured cells that increasing LPP1 activity would decrease...
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Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate
Download2015
Zhao, Yuan Y., McMullen,Todd P. W. , Brindley, David N., Curtis, Jonathan M., Benesch, Matthew G. K.
Autotaxin (ATX) is a secreted enzyme, which produces extracellular lysophosphatidate (LPA) from lysophosphatidylcholine (LPC). LPA activates six G protein-coupled receptors and this is essential for vasculogenesis during embryonic development. ATX is also involved in wound healing and...