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Pathologic Evaluation of Type 2 PorcineReproductive and Respiratory SyndromeVirus Infection at the Maternal-FetalInterface of Late Gestation Pregnant Gilts
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- Author(s) / Creator(s)
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The pathogenesis of fetal death caused by porcine reproductive and respiratory syndromevirus (PRRSV) remains unclear. The objective of this study was to improve our understand-ing of the pathogenesis by assessing potential relationships between specific histopatho-logical lesions and PRRSV RNA concentration in the fetuses and the maternal-fetalinterface. Pregnant gilts were inoculated with PRRSV (n = 114) or sham inoculated (n = 19)at 85±1 days of gestation. Dams and their litters were humanely euthanized and necropsied21 days later. PRRSV RNA concentration was measured by qRT-PCR in the maternal-fetalinterface and fetal thymus (n = 1391). Presence of fetal lesions was positively related toPRRSV RNA concentration in the maternal-fetal interface and fetal thymus (P<0.05 forboth), but not to the distribution or severity of vasculitis, or the severity of endometrial inflam-mation. The presence of fetal and umbilical lesions was associated with greater odds ofmeconium staining (P<0.05 for both). The distribution and severity of vasculitis in endome-trium were not significantly related to PRRSV RNA concentration in maternal-fetal interfaceor fetal thymus. Endometrial inflammation severity was positively related to distribution andseverity of vasculitis in endometrium (P<0.001 for both). Conclusions from this study sug-gest that type 2 PRRSV infection in pregnant gilts induces significant histopathologicallesions at maternal-fetal interface, but they are not associated with presence of PRRSV inthe maternal-fetal interface at 21 days post infection. Conversely, fetal pathological lesionsare associated with presence of PRRSV in the maternal-fetal interface and fetal thymus,and meconium staining is significantly associated with the presence of both fetal and umbili-cal lesions observed 21 days post infection.
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- Date created
- 2016-03-10
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- Subjects / Keywords
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- Porcine Reproductive and Respiratory Syndrome
- Sows
- Pregnancy in mammals
- Swine
- Fetal death
- Histopathy
- Diagnosis
- Diseases
- Anatomy
- Autoimmune diseases
- Biology and life sciences
- Blood vessels
- Cardiovascular anatomy
- Clinical immunology
- Clinical medicine
- Developmental biology
- Embryology
- Endometrium
- Fetuses
- Immune response
- Immune system
- Immunology
- Inflammation
- Inflammatory diseases
- Maternal health
- Medicine in health sciences
- Obstetrics and gynecology
- Pathology and laboratory medicine
- Pregnancy
- Reproductive system
- Research article
- Rheumatology
- Signs and symptoms
- Thymus
- Uterus
- Vasculitis
- Women's health
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- Type of Item
- Article (Published)