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Role of Cytochrome P450 1B1 in Inflammation-induced Cardiac Hypertrophy
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- Author(s) / Creator(s)
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A great deal of research has demonstrated the involvement of cytochrome P450 (CYPs) enzymes and its metabolism of arachidonic acid (AA) in the modulation of cardiac hypertrophy (CH) pathogenesis.
Multiple studies demonstrated that inflammation is a major contributor to CH and is known to modulate the expression of various CYPs in different organs.
Inflammatory cytokines, such as tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and IL-1β are involved in CH pathology.
Enhanced clearance of TNF-α improved cardiac functions in HF. However, the outcomes of two large-scale clinical trials (with infliximab and etanercept) to directly antagonize TNF-α have been rather disappointing, indicating that counteracting this cytokine alone is not sufficient. Also, more mechanisms are required to be unveiled regarding the role of inflammation in CH. -
- Date created
- 2023-05-17
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- Subjects / Keywords
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- Type of Item
- Conference/Workshop Presentation