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- 4Chakrabarti, Subhadeep
- 3Majumder, Kaustav
- 3Proctor, Spencer D.
- 2AlZahal, Ousama
- 2Curtis, Jonathan M.
- 54Graduate and Postdoctoral Studies (GPS), Faculty of
- 54Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 21Agricultural, Food and Nutritional Science, Department of
- 21Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 3Medicine and Dentistry, Faculty of
- 2Pharmacy and Pharmaceutical Sciences, Faculty of
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Chemically defined diet alters the protective properties of fructo-oligosaccharides and isomalto-oligosaccharides in HLA-B27 transgenic rats
Download2014
Koleva, Petya, Ketabi, Ali, Dieleman, Levinus A., Gänzle, Michael G., Valcheva, Rosica
Non-digestible oligosaccharides (NDO) were shown to reduce inflammation in experimental colitis, but it remains unclear whether microbiota changes mediate their colitis-modulating effects. This study assessed intestinal microbiota and intestinal inflammation after feeding chemically defined...
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Design and synthesis of arylthiophene-2-Carbaldehydes via suzuki-miyaura reactions and their biological evaluation
Download2013
Riaz, Muhammad, Zubair, Muhammad, Ali, Shaukat, Rasool, Nasir, Ullah, Aman, Nasim, Faiz-ul-Hassan, Rashid, Umer, Yaqoob, Asma
A series of various novel 4-arylthiophene-2-carbaldehyde compounds were synthesized in moderate to excellent yields via Suzuki-Miyaura cross-coupling with different arylboronic pinacol esters/acids. The synthesized products were screened for their antibacterial, haemolytic, antiurease, and nitric...
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Pathologic Evaluation of Type 2 PorcineReproductive and Respiratory SyndromeVirus Infection at the Maternal-FetalInterface of Late Gestation Pregnant Gilts
Download2016-03-10
Novakovic, Predrag, Harding, John C. S., Al-Dissi, Ahmad, Ladinig, Andrea, Detmer, Susan E.
The pathogenesis of fetal death caused by porcine reproductive and respiratory syndromevirus (PRRSV) remains unclear. The objective of this study was to improve our understand-ing of the pathogenesis by assessing potential relationships between specific histopatho-logical lesions and PRRSV RNA...
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Understanding postprandial inflammation and its relationship to lifestyle behaviour and metabolic diseases
Download2012
Cabezas, Manuel C., Mamo, John C., Proctor, Spencer D., Botham, Kathleen M., Klop, Boudewijn
Postprandial hyperlipidemia with accumulation of remnant lipoproteins is a common metabolic disturbance associated with atherosclerosis and vascular dysfunction, particularly during chronic disease states such as obesity, the metabolic syndrome and, diabetes. Remnant lipoproteins become attached...
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Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers
Download2014
Ueda, Keitaro, Ito, Kazuhiro, Kimura, Genki, Moses, Audric, Xiong, Yeping, Kizawa, Yasuo, Curtis, Jonathan M., Barnes, Peter J., Mercado, Nicolas
Anti-oxidant capacity is crucial defence against environmental or endogenous oxidative stress. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that plays a key defensive role against oxidative and cytotoxic stress and cellular senescence. However, Nrf2...
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Butyrate-mediated genomic changes involved in the non-specific host defenses, matrix remodelling and the immune response in the rumen epithelium of cows afflicted with subacute ruminal acidosis
Download2013
Steele, Michael A., Greenwood, Sabrina L., Plaizier, Jan C., McBride, Brian W., Matthews, James C., Laarman, Anne H., AlZahal, Ousama, Dionissopoulos, Louis
Subacute Ruminal Acidosis (SARA) is a disorder in cattle which can lead to chronic inflammation in the rumen epithelium, known as rumenitis. Butyrate has been shown to attenuate some of the detrimental effects of inflammatory gastroenteral disorders but the molecular mechanisms mediated by...
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Effects of aerobic training on the host systemic milieu in patients with solid tumors: An exploratory correlative study
Download2015
Stevens, Robert D., Courneya, Kerry S., Inman, Brant A., Muehlbauer, Michael, Nelson, Erik R., Jasper, Jeff, Field, Catherine J., Jones, Lee W., Glass, Oliver K., Bain, James R., Broadwater, Gloria, Goruk, Susan, Hirschey, Matthew D., Mackey, John R.
background: Few studies have investigated the effects of exercise on modulation of host factors in cancer patients. We investigated the efficacy of chronic aerobic training on multiple host-related effector pathways in patients with solid tumours. patients and methods: Paired peripheral blood...
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Vaccenic and elaidic acid modify plasma and splenocyte membrane phospholipids and mitogen-stimulated cytokine production in obese insulin resistant JCR:LA-cp rats
Download2010
Ruth, Megan R., Reaney, Martin J., Vine, Donna F., Goruk, Susan, Yu, Howe-Ming, Field, Catherine J., Proctor, Spencer D., Wang, Ye
This study assessed the long-term effects of dietary vaccenic acid (VA) and elaidic acid (EA) on plasma and splenocyte phospholipid (PL) composition and related changes in inflammation and splenocyte phenotypes and cytokine responses in obese/insulin resistant JCR:LA-cp rats. Relative to lean...
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Role of Cytochrome P450 1B1 in Inflammation-induced Cardiac Hypertrophy
2023-05-17
ElKhatib, Mohammed, El-Kadi, Ayman
A great deal of research has demonstrated the involvement of cytochrome P450 (CYPs) enzymes and its metabolism of arachidonic acid (AA) in the modulation of cardiac hypertrophy (CH) pathogenesis. Multiple studies demonstrated that inflammation is a major contributor to CH and is known to...