Search
Skip to Search Results-
Fall 2022
Multiple Sclerosis (MS) is a chronic neurodegenerative disease which is mainly characterized by inflammation, demyelination, and axonal loss. Conventional Magnetic Resonance Imaging (MRI) has become the most established imaging tool in the diagnosis and follow-up of MS in clinical practice....
-
Advances in Quantitative Susceptibility Mapping for Human Brain: Applications in Hemorrhage, Motion, Blood Vessels
DownloadFall 2022
Quantitative Susceptibility Mapping (QSM) is an emerging postprocessing method, computed from phase images, which is finding wide application in quantifying iron content in healthy and pathological tissue. However, QSM is still not commonly used in clinical practice. This thesis discusses the...
-
Fall 2016
Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI) noninvasive method, capable of measuring perfusion, i.e. blood flow, with blood as an intrinsic contrast. ASL measurements of cerebral perfusion are usually acquired at very low spatial resolution (> 60mm3 voxels), for several...
-
Spring 2019
The invention of magnetic resonance imaging (MRI) has advanced the diagnosis of diseases dramatically as it is capable of producing high-quality images of soft tissues non-invasively and safely. However, the high volume of MRI images also means heavy workloads for physicians, which results in...
-
Fall 2014
Diffusion magnetic resonance imaging (dMRI) measures the diffusion (i.e. random molecular motion) of water. Since the motion of water is inhibited by cellular membranes, dMRI provides insight into the microstructural characteristics of the tissue. However, distinguishing between small anatomical...
-
Fall 2016
Neurological disorders are among major causes of disability in Canada. In the diagnostic procedure, Magnetic Resonance Imaging (MRI) is commonly used as it is non-invasive and can produce dramatic contrast between different brain tissues. Brain tissue segmentation is a fundamental step in brain...
-
Fall 2015
Fats are a fundamental building block of the human body, but accumulation of unwanted fat in and around tissues is a common pathology related to many disease mechanisms. Magnetic Resonance Imaging (MRI) offers a host of methods to differentiate water and fat signals in images or spectra, for...
-
Magnetic Resonance Imaging of the Brain in Prenatal Alcohol Exposure and Advances in Measuring Cortical Microstructure
DownloadFall 2020
Fetal alcohol spectrum disorder (FASD) encompasses a large spectrum of physical, cognitive and behavioral deficits resulting from prenatal alcohol exposure. Studies using magnetic resonance imaging (MRI) have shown structural and functional brain alterations in children and adolescents with...
-
Fall 2021
Tracking myelination and demyelination in the brain is a crucial part of studies on neurodegenerative diseases such as Multiple Sclerosis (MS). Classic MRI techniques are unable to provide enough information about the pathology of tracts and lesions. Multi-component analysis of multi-echo data...
-
Fall 2014
Osteoarthritis (OA) is characterized by progressive destruction of articular cartilage, subchondral bone sclerosis, and osteophyte formation. Currently there is no disease modifying drug for treatment of OA. Usually OA is not diagnosed until the advanced stages, where palliative treatment is the...