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Efficient Technique for Corpus Callosum Segmentation in Midsagittal Brain MR Images

  • Author / Creator
    Li, Yue
  • Neurological disorders are among major causes of disability in Canada. In the diagnostic procedure, Magnetic Resonance Imaging (MRI) is commonly used as it is non-invasive and can produce dramatic contrast between different brain tissues. Brain tissue segmentation is a fundamental step in brain MR images analysis. Corpus Callosum (CC) is an important brain tissue and is always adopted as the landmark of human brain. In this thesis, we propose an intelligent computer-aided detection (CAD) system for automatic segmentation of CC in T1-weighted midsagittal brain MRI slices. The proposed CAD system has three modules: Adaptive Mean Shift Clustering (AMS), Automated CC Contour Initialization (ACI), and Geometric Active Contour (GAC) based Segmentation. In the first module, homogenous regions in the input image are divided into clusters with an adaptive mean shift clustering method. In the second module, area analysis, template matching, shape and location analysis are used to identify the cluster that contains CC and extract a rough boundary of CC as the initial contour. In the last module, the boundary of recognized CC region is used as the initial contour in the GAC model, and is evolved to obtain the final segmentation result of CC. Experimental results demonstrate that the proposed AMS-ACI technique is able to provide accurate initial CC contour, and the proposed AMS-ACI-GAC technique overcomes the problem of user-guided initialization in existing GAC techniques, and provides a reliable and accurate performance in CC segmentation.

  • Subjects / Keywords
  • Graduation date
    2016-06:Fall 2016
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R3707WW9F
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Department of Electrical and Computer Engineering
  • Specialization
    • Signal and Image Processing
  • Supervisor / co-supervisor and their department(s)
    • Mrinal K. Mandal, Department of Electrical and Computer Engineering
    • S. Nizam Ahmed, Department of Medicine
  • Examining committee members and their departments
    • Jie Chen, Department of Electrical and Computer Engineering
    • Roger Zemp, Department of Electrical and Computer Engineering