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Technical report TR11-02. Given two genomic maps G1 and G2 each represented as a sequence of n gene markers, the maximal strip recovery (MSR) problem is to retain the maximum number of markers in both G1 and G2 such that the resultant subsequences, denoted as G1* and G2*, can be partitioned into...
Multiple sclerosis (MS) is a common cause of non-traumatic neurologic disability with high incidence in many developed countries. Although the etiology of the disease remains elusive, it is thought to entail genetic and environmental causes, and microbial pathogens have also been envisioned as...
Metabolomics involves the high throughput characterization of small molecules or metabolites in cells, tissues and organisms. To interpret, store and exchange metabolomic data it is necessary to have comprehensive, electronically accessible databases that can be used to handle both the...
Metabolomics aims to study all small-molecule compounds (i.e. metabolites) in cells, tissues, or biofluids. These compounds provide a functional readout of the physiological, developmental, and pathological state of a biological system. The field of metabolomics has expanded rapidly over the last...
Recent advances in high-throughput technologies, such as genome-wide SNP analysis and microar- ray gene expression profiling, have led to a multitude of ranked lists, where the features (SNPs, genes) are sorted based on their individual correlation with a phenotype. Multiple reviews have shown...
Technical report TR03-09. Naive Bayes classifiers, a popular tool for predicting the labels of query instances, are typically learned from a training set. However, since many training sets contain noisy data, a classifier user may be reluctant to blindly trust a predicted label. We present a...
Technical report TR01-10. For two DNA or protein sequences of length m and n, dynamic programming alignment algorithms like Needleman-Wunsch and Smith-Waterman take O(m x n) time and use O(m x n) space, so we refer to them as full matrix (FM) algorithms. This space requirement means that large...
Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humansDownload
Wen, Xiao-Yan, Hegele, Robert A., Wang, Jian, Wang, Ding Yan, Cheung, Joseph, Wilson, Michael, Yahyapour, Maryam, Bai, Yahong, Zhuang, Lihua, Skaug, Jennifer, Young, T. Kue, Connelly, Philip W., Koop, Ben F., Tsui, Lap-Chee, Stewart, A. Keith
"Triglyceride (TG) metabolism is crucial for whole body and local energy homeostasis and accumulating evidence suggests an independent association between plasma TG concentration and increased atherosclerosis risk. We previously generated a mouse insertional mutation lpd (lipid defect) whose...
Changes in gene expression have been thought to play a crucial role in various types of cancer. With the advance of high-throughput experimental techniques, many genome-wide studies are underway to analyze underlying mechanisms that may drive the changes in gene expression. It has been observed...