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Skip to Search Results- 3Fliegel, Larry
- 3Sykes, Brian D.
- 2Lee, Brian L.
- 2Li, Xiuju J.
- 1Abdul Rahman, Siti Aishah
- 1Acedo, Jeella Z
- 21Graduate and Postdoctoral Studies (GPS), Faculty of
- 21Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 3Biochemistry, Department of
- 3Biochemistry, Department of/Journal Articles (Biochemistry)
- 2Agricultural, Food and Nutritional Science, Department of
- 2Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 8Department of Chemistry
- 3Faculty of Pharmacy and Pharmaceutical Sciences
- 2Department of Chemical and Materials Engineering
- 2Department of Oncology
- 1Department of Agricultural, Food, and Nutritional Science
- 1Department of Biochemistry
- 4Vederas, John (Chemistry)
- 2Unsworth, Larry (Chemical and Materials Engineering)
- 1Derda, Ratmir
- 1Dr. Kaur, Kamaljit (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Kaur, Kamaljit (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Lavasanifar, Afsaneh (Faculty of Pharmacy and Pharmaceutical Sciences)
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Spring 2016
Biomining is an efficient way for improving mineral extraction and remediation processes. Using specific/targeted separation is a promising method to increase purification yield of minerals and metals at low cost. In traditional methods extraction and purification of the desired materials from...
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Light Responsive Linchpins for Accelerated Discovery of Light-Responsive Mono- and Bicyclic Peptide Ligands
DownloadSpring 2016
In this thesis I describe the development and application of light-responsive (LR) linchpins for efficient discovery of LR-peptides from genetically encoded peptide librar-ies. LR-linchpins have been used for dynamic control of the structure of peptides and their biochemical properties such as...
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1992
Forsyth, George W., Romancyia, D. A., Uwiera, Richard R. E., Wong, Jonathan P.
The B subunit of cholera toxin has been covalently attached to the surface of Uposomes made from a mixture of phosphatidylethanolamine, phosphati- dylcholine and cholesterol. Adenylate cydase inhibitors and chloride conduc- tance inhibitors were encapsulated within the liposomes. These...
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Oxidative stress mediates estrogen receptor independent killing and contributes to tamoxifen resistance
Download2016
Godbout, Roseline, Brindley, David N., McMullen, Todd, Mackey, John R., Benesch, Matthew, Mi, Si, Venkatraman, Ganesh, Liu, Rong-Zong, Curtis, Jonathan M., Tang, Xiaoyun, Bekele, Raie T.
Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...
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Structural and functional analysis of transmembrane segment VI of the NHE1 isoform of the na+/H+ exchanger
Download2009-01-01
Tzeng, Jennifer, Lee, Brian L., Sykes, Brian D., Fliegel, Larry
The Na+/H+ exchanger isoform 1 is a ubiquitously expressed integral membrane protein. It resides on the plasma membrane of cells and regulates intracellular pH in mammals by extruding an intracellular H+ in exchange for one extracellular Na+. We characterized structural and functional aspects of...
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Structural and functional analysis of transmembrane XI of the NHE1 isoform of the na+/H+ exchanger
Download2009-01-01
Lee, Brian L., Li, Xiuju J., Liu, Yongsheng, Sykes, Brian D., Fliegel, Larry
The Na+/H+ exchanger isoform 1 is a ubiquitously expressed integral membrane protein that regulates intracellular pH in mammals by extruding an intracellular H+ in exchange for one extracellular Na+. We characterized structural and functional aspects of the critical transmembrane (TM) segment XI...
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Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the na+/H+ exchanger
Download2005-01-01
Slepkov, Emily R., Rainey, Jan K., Li, Xiuju J., Liu, Yonghsheng S., Cheng, Florence J., Lindhout, Darrin A., Sykes, Brian D., Fliegel, Larry
The Na+/H+ exchanger isoform 1 is a ubiquitously expressed integral membrane protein that regulates intracellular pH in mammals. We characterized the structural and functional aspects of the critical transmembrane (TM) segment IV. Each residue was mutated to cysteine in cysteine-less NHE1. TM IV...