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- 3Godbout, Roseline
- 2Field, Catherine J.
- 1Beaulieu, Michael J.
- 1Bekele, Raie T.
- 1Benesch, Matthew
- 1Brindley, David N.
Brain fatty acid-binding protein and ω-3/ω-6 fatty acids: Mechanistic insight into the poor prognosis of malignant glioma cell migrationDownload
Malignant gliomas (MG) are highly infiltrative tumors that consistently recur despite aggressive treatment. Brain fatty acid-binding protein (FABP7), which binds docosahexaenoic acid (DHA) and arachidonic acid (AA), localizes to sites of tumor infiltration and is associated with a poor prognosis...
Long-term effect of docosahexaenoic acid feeding on lipid composition and brain fatty acid-binding protein expression in ratsDownload
Arachidonic (AA) and docosahexaenoic acid (DHA) brain accretion is essential for brain development. The impact of DHA-rich maternal diets on offspring brain fatty acid composition has previously been studied up to the weanling stage; however, there has been no follow-up at later stages. Here, we...
Oxidative stress mediates estrogen receptor independent killing and contributes to tamoxifen resistanceDownload
Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...