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- 2Brindley, David N.
- 2Curtis, Jonathan M.
- 2Tang, Xiaoyun
- 1Bekele, Raie T.
- 1Benesch, Matthew
- 1Benesch, Matthew G. K.
Lipid phosphate phosphatase-1 expression in cancer cells attenuates tumor growth and metastasis in miceDownload
Lipid phosphate phosphatase-1 (LPP1) degrades lysophosphatidate (LPA) and attenuates receptor-mediated signaling. LPP1 expression is low in many cancer cells and tumors compared with normal tissues. It was hypothesized from studies with cultured cells that increasing LPP1 activity would decrease...
Oxidative stress mediates estrogen receptor independent killing and contributes to tamoxifen resistanceDownload
Tamoxifen is the accepted therapy for patients with estrogen receptor-α (ERα)-positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...