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Skip to Search Results- 6Graduate and Postdoctoral Studies (GPS), Faculty of
- 6Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 5Agricultural, Food and Nutritional Science, Department of
- 5Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 3Roy Berg Kinsella Research Ranch
- 3Roy Berg Kinsella Research Ranch/Journal Articles (Kinsella Ranch)
- 1Damaraju, Sambasivarao (Medical Sciences - Laboratory Medicine and Pathology)
- 1Dr. Changxi Li (Agricultural, Food & Nutritional Science)
- 1Guan, Leluo (Department of Agricultural, Food, and Nutritional Science, University of Alberta)
- 1Hobman, Tom (Department of Cell Biology)
- 1Lin, Guohui (Computing Science)
- 1Paul Stothard, Department of Agricultural, Food and Nutritional Science
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2013-01-01
Basu, Urmila, Josue, Romao Moura, Guan, LeLuo
The recent technological innovations in the area of functional genomics, gene expression/transcriptomic profiling can provide new insights to understand the molecular basis of adipogenesis. The focus of this review is to highlight the recent advances in our understanding of the complex interplay...
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Characterization of microRNA expression in bovine adipose tissues: A potential regulatory mechanism of subcutaneous adipose tissue development
Download2010
Jin, W., Guan, L., Dodson, M. V., Basarab, J. A., Moore, S. S.
Background MicroRNAs (miRNAs), a family of small non-coding RNA molecules, appear to regulate animal lipid metabolism and preadipocyte conversion to form lipid-assimilating adipocytes (i.e. adipogenesis). However, no miRNA to date has been reported to modulate adipogenesis and lipid deposition...
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Drug Resistance in Breast Cancer: Characterization of Rationally Designed Paclitaxel Analogs in Model Systems
DownloadFall 2013
Breast cancer is a leading cause of cancer related deaths among women in the developed world. Treatment options for breast cancer include taxanes, which mediate cytotoxic effects by inducing microtubule polymerization which impedes cell division. Taxane resistant breast cancer is a mounting...
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Spring 2014
Adipose tissue plays an important role in the energetic balance, but it is also an important aspect of meat quality and animal productivity. However, the understanding on how fat metabolism is regulated in beef cattle is not clear. This research aimed at exploring how bovine adipose tissue is...
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Genetic and genomic basis of antibody response to porcine reproductive and respiratory syndrome (PRRS) in gilts and sows
Download2016-01-01
Serao, Nick V. L., Kemp, Robert A., Mote, Benny E., Willson, Philip, Harding, John C. S., Bishop, Stephen C., Plastow, Graham S., Dekkers, Jack C. M.
Background:Our recent research showed that antibody response to porcine reproductive and respiratory syn-drome (PRRS), measured as sample-to-positive (S/P) ratio, is highly heritable and has a high genetic correlation with reproductive performance during a PRRS outbreak. Two major quantitative...
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Hsp90 and its co-chaperones regulate the activity of human Argonaute2 in RNA-mediated silencing pathways
DownloadFall 2011
The potent ability of small, double-stranded RNAs to silence gene expression was initially reported 1998, sparking revolutions in molecular biology and genetics. Since then, intensive research into the mechanism of RNA-mediated silencing has implicated the machinery of this pathway in the...
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Identification of functional genes for feed efficiency traits via transcriptome analyses to enhance the genomic prediction accuracy in beef cattle
DownloadFall 2019
Residual feed intake (RFI), a measure of feed efficiency, and its component traits including average daily gain (ADG), dry matter intake (DMI) and metabolic weight (MWT) are traits of great economic importance to the beef industry. The genetic improvement of these traits can improve the...
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Improving Accuracy of Genomic Prediction for Economically Important Traits in Canadian Holstein Dairy Cattle
DownloadSpring 2017
Milk is a valuable source of energy, high quality protein, and several key minerals and vitamins for humans. Selection for milk production in dairy cattle was first based on phenotype and pedigree information and the knowledge of genetic parameters for the trait of interest. However, substantial...
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Initial differences in lipid processing leading to pig- and beef-derived mature adipocyte dedifferentiation
Download2009
Fernyhough, Melinda E., Hausman, Gary J., Guan, Leluo, Guridi, Maitea, Jiang, Zhihua, Dodson, Michael V., Chen, Jie
Clonal cultures of pig-derived mature adipocytes are capable of dedifferentiating and forming proliferative-competent progeny cells in vitro. Initial lipid processing, is different to that observed in cultures of beef-derived adipocytes. Mature pig adipocytes extrude lipid before proliferation,...
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Lipid metabolism, adipocyte depot physiology and utilization of meat animals as experimental models for metabolic research
Download2010-01-01
Dodson, Michael V., Hausman, Gary J., Guan, LeLuo, Du, Min, Rasmussen, Theodore P., Poulos, Sylvia P., Mir, Priya, Bergen, Werner G., Fernyhough, Melinda E., McFarland, Douglas C., Rhoads, Robert P., Soret, Beatrice, Reecy, James M., Velleman, Sandra G., Jiang, Zhihua
Meat animals are unique as experimental models for both lipid metabolism and adipocyte studies because of their direct economic value for animal production. This paper discusses the principles that regulate adipogenesis in major meat animals (beef cattle, dairy cattle, and pigs), the definition...