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Initial differences in lipid processing leading to pig- and beef-derived mature adipocyte dedifferentiation
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- Author(s) / Creator(s)
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Clonal cultures of pig-derived mature adipocytes are capable of dedifferentiating and forming proliferative-competent progeny cells in vitro. Initial lipid processing, is different to that observed in cultures of beef-derived adipocytes. Mature pig adipocytes extrude lipid before proliferation, whereas beef-derived adipocytes symmetrically, or asymmetrically, divide without expelling lipid. These observations suggest that dedifferentiation of mature adipocytes relies on species-specific mechanisms, or that different culture conditions are required for pigderived adipocytes to dedifferentiate in a manner similar to beef adipocytes. This in vitro system will aid in our understanding of lipid metabolism, regulation of single cells, processes involved in dedifferentiation of cells, and/or characteristics of putative stem cells residing in adipose tissue.
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- Date created
- 2009
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- Subjects / Keywords
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- Type of Item
- Article (Published)
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- License
- Attribution-NonCommercial 4.0 International