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- 9Dekkers, Jack C. M.
- 8Plastow, Graham S.
- 5Harding, John C. S.
- 4Lunney, Joan K.
- 4PigGen Canada
- 3Dyck, Michael K.
Comparison of host genetic factors influencing pig response to infection with two North American isolates of porcine reproductive and respiratory syndrome virusDownload
Background:Porcine reproductive and respiratory syndrome (PRRS) is one of the most important swine diseases in the world and genetic selection of pigs for increased resistance to PRRS is an attractive method to improve the health status of the swine herd. This study compared phenotypic and...
Exploring Phenotypes for Disease Resilience in Pigs Using Complete Blood Count Data From a Natural Disease Challenge ModelDownload
Disease resilience is a valuable trait to help manage infectious diseases in livestock. It is anticipated that improved disease resilience will sustainably increase production efficiency, as resilient animals maintain their performance in the face of infection. The objective of this study was to...
Genetic and genomic basis of antibody response to porcine reproductive and respiratory syndrome (PRRS) in gilts and sowsDownload
Background:Our recent research showed that antibody response to porcine reproductive and respiratory syn-drome (PRRS), measured as sample-to-positive (S/P) ratio, is highly heritable and has a high genetic correlation with reproductive performance during a PRRS outbreak. Two major quantitative...
Genetic architecture of gene expression underlying variation in host response to porcine reproductive and respiratory syndrome virus infectionDownload
Kommadath, Arun, Bao, Hua, Choi, Igseo, Reecy, James M., Koltes, James E., Fritz-Waters, Elyn, Eisley, Chris J., Grant, Jason R., Rowland, Robert R. R., Tuggle, Christopher K., Dekkers, Jack C. M., Lunney, Joan K., Guan, Le Luo, Stothard, Paul, Plastow, Graham S.
It has been shown that inter-individual variation in host response to porcine reproductive and respiratory syndrome (PRRS) has a heritable component, yet little is known about the underlying genetic architecture of gene expression in response to PRRS virus (PRRSV) infection. Here, we integrated...
Genomic Analysis of IgG Antibody Response to Common Pathogens in Commercial Sows in Health-Challenged HerdsDownload
Losses due to infectious diseases are one of the main factors affecting productivity in the swine industry, motivating the investigation of disease resilience-related traits for genetic selection. However, these traits are not expected to be expressed in the nucleus herds, where selection is...
Genomic Prediction of Piglet Responses to Infection with One or Two Porcine Reproductive and Respiratory Syndrome Virus IsolatesDownload
Genomic prediction of the pig’s response to the porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) would be a useful tool in the swine industry. This study investigated the accuracy of genomic prediction based on porcine SNP60 Beadchip data using training and validation datasets...
Novel Resilience Phenotypes Using Feed Intake Data From a Natural Disease Challenge Model in Wean-to-Finish PigsDownload
The objective of this study was to extract novel phenotypes related to disease resilience using daily feed intake data from growing pigs under a multifactorial natural disease challenge that was designed to mimic a commercial environment with high disease pressure to maximize expression of...
Background:Gene expression profiling in blood is a potential source of biomarkers to evaluate or predict phenotypic differences between pigs but is expensive and inefficient because of the high abundance of globin mRNA in porcine blood. These limitations can be overcome by the use of QuantSeq...
The genetic basis of natural antibody titersof young healthy pigs and relationshipswith disease resilienceDownload
Background Disease resilience is the ability to maintain performance under pathogen exposure but is difficult to select for because breeding populations are raised under high health. Selection for resilience requires a trait that is heritable, easy to measure on healthy animals, and genetically...