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Pre-clinical Evaluation of Iodoazomycin Arabinofuranoside (IAZA) and Fluoroazomycin Arabinofuranoside (FAZA) as Hypoxia-targeting Therapeutic Agents in a Head and Neck Cancer Model
DownloadSpring 2022
Tumour hypoxia is a well-recognized clinical problem that promotes resistance to anti-cancer treatment (chemotherapy, radiotherapy, and immunotherapy), increases rates of recurrent disease, and ultimately leads to poor patient outcome. Eradication of hypoxic tumours is, therefore, essential for...
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Carbon Dynamics across Contrasting Temperate Agroecosystems: Soil Organic Matter Pools, Mycorrhizae, Water Use-efficiency, Methane and Carbon Dioxide Fluxes
DownloadSpring 2022
Perennial grain crops have been proposed as a sustainable alternative to conventional annual grain crops, since they potentially hold multiple desirable features including increased soil C sequestration and biodiversity, mitigation of greenhouse gases (GHGs), and reduction of water loss and...
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Development of dynamic column breakthrough for multicomponent adsorption equilibrium and diffusion
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Pressure and temperature swing adsorption processes are increasingly being designed and optimized computationally. The reliability of these predictions are highly dependent on the quality of the experimental equilibrium and kinetic data used in these simulations. Consistent experimental...
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Fabrication of an organic electrochemical transistor for the detection of Escherichia coli O157:H7 in liquid samples
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Aguilar Vallejo, Angelica Isabel
Escherichia coli O157:H7 is an enterohaemorrhagic bacteria which produces Shiga toxins 1 and 2; this strain is responsible for several outbreaks due to contaminated food and water. In order to prevent future outbreaks and maintain the public safe from infections, different microbiological...
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Spring 2022
In this thesis, we investigate the use of single-image depth prediction from convolutional neural networks (CNNs) in sparse and dense monocular visual simultaneous localization and mapping (SLAM) problems. Mainly, we are interested in solving three problems: (1) data association, (2) dense...
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Binding Topologies of Amino Acid Binary Systems by Infrared Multiphoton Dissociation (IRMPD) Spectroscopy
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Studies of amino acids are essential because they are one of the building blocks of larger biomolecules, and it is crucial for us to understand how they interact with each other to fulfill all these various biological functions in our daily life. One interesting and noticeable fact from previous...
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Methodology for Project Schedule Acceleration Integrated with Energy Source-Based Assessment of Occupational Health and Safety Risks
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There will always be uncertainties and hazards involved with project activities in the construction industry. Both long-term and short-term safety events reported to occupational health and safety authorities are impacted by the practice of schedule compression by crashing the project activities....
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Molecular Modeling of Gas Adsorption, Phase Behaviors, and Surface Area Characterization in Shale Organic Nanoporous Media
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Shale gas plays an increasingly important role in meeting the growing global energy demand and reducing carbon emissions. Unlike conventional reservoirs, shale, including both organic and inorganic matter, can have an extensive amount of pores ranging from a few to hundreds of nanometers....
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Investigating and characterizing the direct binding interactions between chemotherapeutic cisplatin and pattern recognition receptor, Toll-like Receptor 4
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Cisplatin is one of the most effective chemotherapeutic agents available. Unfortunately, adverse drug reactions - cisplatin-induced toxicities - often limit the use of cisplatin. These toxicities develop in at least half of those treated, are diverse, and are especially problematic for pediatric...
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Exploring the Association Between Frailty and Adverse Clinical Outcomes in Inflammatory Bowel Disease
DownloadFall 2022
Background and Rationale: Chronological age does not always accurately reflect “biological age”, or the extent of physiological reserve an individual possesses to endure stressors. The concept of physiological reserve is best represented by frailty; a multifaceted syndrome or state that...