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Skip to Search Results- 16Graduate and Postdoctoral Studies (GPS), Faculty of
- 16Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 7Chemistry, Department of
- 7Chemistry, Department of/Journal Articles (Chemistry)
- 2Biological Sciences, Department of
- 2Biological Sciences, Department of/Journal Articles (Biological Sciences)
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Spring 2023
For more than 70 years, chemists have used Nuclear Magnetic Resonance (NMR) spectroscopy to characterize the atomic structure and dynamics of molecules. Key to performing the NMR analysis of almost any molecule is a process called “chemical shift assignment”. This involves matching specific peaks...
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2006
Wishart, D.S., Neal, S., Berjanskii, M.V.
Every year between 500 and 1000 peptide and protein structures are determined by NMR and deposited into the Protein Data Bank. However, the process of NMR structure determination continues to be a manually intensive and time-consuming task. One of the most tedious and error-prone aspects of this...
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2010-01-01
PROSESS (PROtein Structure Evaluation Suite and Server) is a web server designed to evaluate and validate protein structures generated by X-ray crystallography, NMR spectroscopy or computational modeling. While many structure evaluation packages have been developed over the past 20 years, PROSESS...
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Fall 2009
This thesis is concerned with applications of modern solid-state NMR spectroscopy. Investigations of three quite different types are undertaken, each of which attempt to advance knowledge in the fields of chemistry and NMR. The goal of each project is to obtain insight into the effects of...
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Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the na+/H+ exchanger
Download2005-01-01
Slepkov, Emily R., Rainey, Jan K., Li, Xiuju J., Liu, Yonghsheng S., Cheng, Florence J., Lindhout, Darrin A., Sykes, Brian D., Fliegel, Larry
The Na+/H+ exchanger isoform 1 is a ubiquitously expressed integral membrane protein that regulates intracellular pH in mammals. We characterized the structural and functional aspects of the critical transmembrane (TM) segment IV. Each residue was mutated to cysteine in cysteine-less NHE1. TM IV...
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Structural and functional characterization of transmembrane segment VII of the na+/H+ exchanger isoform 1
Download2006-01-01
Ding, Jie, Rainey, Jan K., Xu, Caroline, Sykes, Brian D., Fliegel, Larry
The Na+/H+ exchanger isoform 1 is an integral membrane protein that regulates intracellular pH by exchanging one intracellular H+ for one extracellular Na+. It is composed of an N-terminal membrane domain of 12 transmembrane segments and an intracellular C-terminal regulatory domain. We...
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Structural aspects of the interaction of the cytoplasmic domain of Mucin-1 (MUC1) with the SH3 domain of Src Kinase
DownloadFall 2011
Marasinghe Arachchige, Bodhi Nirosha
Abstract Breast cancer is the second most frequent cause of cancer deaths in Canadian women with death resulting from the spread of cancer cells or metastasis to distal organs. Our laboratory was the first to show that MUC1, a type-1 transmembrane glycoprotein highly overexpressed in breast...
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Structure and dynamics of biomolecules: probing muscle regulation, prion protein unfolding, and drug insertion into DNA by nuclear magnetic resonance spectroscopy
DownloadSpring 2011
Nuclear magnetic resonance (NMR) spectroscopy is a powerful approach to study the structure and dynamics of macromolecules in a close-to-native solution environment. In the present thesis I present my investigation of protein and nucleic acid structure and dynamics in a wide variety of biological...
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Study of Methylammonium Lead Triiodide Intrinsic Stability and Solid-Solution behaviour in Mixed Halide Perovskite Systems
DownloadFall 2018
Askar, Abdelrahman Mostafa Mohamed Sanad
Over the last nine years, a new class of materials named lead halide perovskite has made a paradigm shift in the field of optoelectronic solution-processable low-cost and high-efficiency devices, with outstanding accomplishments especially in the ever-growing field of renewable solar energy...
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2022-01-01
Cyclic tetraaryl[5]cumulenes (1a–f) have been synthesized and studied as a function of increasing ring strain. The magnitude of ring strain is approximated by the extent of bending of the cumulenic core as assessed by a combination of X-ray crystallographic analysis and DFT calculations. Trends...