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- 2Fliegel, Larry
- 2Rainey, Jan K.
- 2Sykes, Brian D.
- 2Wishart, D.S.
- 1Askar, Abdelrahman Mostafa Mohamed Sanad
- 1Berjanskii, M.V.
- 10Graduate Studies and Research, Faculty of
- 10Graduate Studies and Research, Faculty of/Theses and Dissertations
- 2Biological Sciences, Department of
- 2Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 2Biochemistry, Department of
- 2Biochemistry, Department of/Journal Articles (Biochemistry)
The Na+/H+ exchanger isoform 1 (NHE1) is the predominant isoform in mammalian cells, and regulates intracellular pH and ion concentrations. NHE1 also interacts with numerous proteins and signalling pathways. Consequently, it has been found to influence cell volume, growth, differentiation, and...
J-Coupling Effects on Quantification of the 1.3 ppm Lipid Methylene Resonance with In-Vivo Magnetic Resonance Spectroscopy at 3 TDownload
Quantification of 1.3 ppm lipid methylene protons by proton magnetic resonance spectroscopy has been shown to be relevant to a number of diseases. Additionally, T2 estimation of 1.3 ppm methylene protons has been used to grade the metastatic potential of colon tumours. J-coupling...
Mechanisms of Prion Disease: Initial Misfolding of the Prion Protein and Metabolomic Changes in the BrainDownload
Prion diseases are neurodegenerative diseases that are caused by the misfolding and aggregation of cellular prion protein (PrPC) into the pathogenic form termed PrPSc. To contribute to a better understanding of the mechanism of prion disease, in this thesis I present my work on the structural...
Metabolomics is a newly emerging field of ‘omics’ research that is concerned with characterizing large numbers of metabolites using NMR, chromatography and mass spectrometry. It is frequently used in biomarker identification and the metabolic profiling of cells, tissues or organisms. The data...
A fine balance between contraction and relaxation is crucial for the heart to function properly. But often the heart cannot contract with enough force to meet the demands of the body. This condition, called systolic heart failure, is the leading cause of death in the modern society. A common...
Nuclear Magnetic Resonance metabolomic fingerprint of the Interleukin 10 gene deficient mouse model of Inflammatory Bowel DiseaseDownload
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder that occurs as a consequence of a genetic mutation that results in an overly aggressive immune response to normal bacteria. Metabolomics is a new born cousin to genomics and proteomics and involves a high throughput...
Every year between 500 and 1000 peptide and protein structures are determined by NMR and deposited into the Protein Data Bank. However, the process of NMR structure determination continues to be a manually intensive and time-consuming task. One of the most tedious and error-prone aspects of this...
PROSESS (PROtein Structure Evaluation Suite and Server) is a web server designed to evaluate and validate protein structures generated by X-ray crystallography, NMR spectroscopy or computational modeling. While many structure evaluation packages have been developed over the past 20 years, PROSESS...
This thesis is concerned with applications of modern solid-state NMR spectroscopy. Investigations of three quite different types are undertaken, each of which attempt to advance knowledge in the fields of chemistry and NMR. The goal of each project is to obtain insight into the effects of...