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- 1Blackmore, Derrick
- 1Borzouie, Shima
- 1Chan, Angela W
- 1Curle, Jared P
- 1Davis, Vanessa W
- 1Dawe, Margot Renee
The simultaneous quantification of all biological molecules, from metabolites to proteins, holds the key to discovering molecular signatures that can diagnose diseases before irreversible damages have occurred in the body. Recent advances in the field of liquid chromatography coupled mass...
Application of ROC curve analysis to metabolomics data sets for the detection of cancer in a mouse modelDownload
The goal of this study was to show that quantifiable metabolic changes may be used to screen for cancer. NIH III nude mice (n=22) were injected with human GBM cells, with daily urine samples collected pre and post-injection. 14 mice were injected with saline to serve as controls. The...
Food is fundamental to life. It is the source of essentially all the chemical and biological components found in our bodies. Given its importance, there is a growing desire among food producers, consumers, nutritionists, and dieticians to have a better understanding of the precise chemical...
Beyond the Antibodies: Sera Metabolomic Biomarker Signatures Discriminate Myasthenic And Healthy CohortsDownload
Myasthenia Gravis (MG) is a chronic, potentially debilitating autoimmune disease characterized by weakness and rapid fatigue of the voluntary muscles that worsens on exertion and improves on rest. Left untreated, MG symptoms may cause significant morbidity, affecting occupational performance,...
Breaking the wall of silence of trees Mining metabolomics to describe hybridization and predict performance in the Populus – Sphaerulina musiva pathosystemDownload
Stem canker diseases in poplars caused by the fungal pathogen Sphaerulina musiva Peck. remain some of the least understood forest diseases despite causing considerable damage, particularly in hybrid poplar plantations. S. musiva is endemic to eastern Canada in provinces including the Maritimes,...
The objective of this work was to employ differential 13C/12C dansyl chloride (DnsCl) derivatization strategies for qualitative and quantitative profiling of amine- and phenol-containing metabolites by liquid chromatography electrospray ionization Fourier Transform ion cyclotron resonance mass...
Metabolomics involves the high throughput characterization of small molecules or metabolites in cells, tissues and organisms. To interpret, store and exchange metabolomic data it is necessary to have comprehensive, electronically accessible databases that can be used to handle both the...
Metabolomics aims to study all small-molecule compounds (i.e. metabolites) in cells, tissues, or biofluids. These compounds provide a functional readout of the physiological, developmental, and pathological state of a biological system. The field of metabolomics has expanded rapidly over the last...
Development and Application of Chemical Isotope Labeling Methods for Metabolomics Data Processing and Liquid Chromatography-Mass Spectrometry-Based MetabolomicsDownload
Metabolomics is the study of chemical processes involving small-molecule metabolites in a given biological system. These small molecules are downstream outputs of cellular activities. An understanding of the metabolome change can help us to visualize perturbations in the genome or proteome from...
Development and Applications of Chemical Isotope Labeling Methods for Metabolome Sample Normalization and Liquid Chromatography-Mass Spectrometry-Based MetabolomicsDownload
Metabolomics refers to the global study of the metabolome of a biological system where comprehensive and systematic profiling of all metabolites in a given biological sample (i.e., the metabolome) is performed. As the end product of biological processes, the status of metabolites could reflect...