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Skip to Search Results- 5Field, Catherine J.
- 4Proctor, Spencer D.
- 3Chakrabarti, Subhadeep
- 3Wu, Jianping
- 2AlZahal, Ousama
- 2Dionissopoulos, Louis
- 53Graduate and Postdoctoral Studies (GPS), Faculty of
- 53Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 19Agricultural, Food and Nutritional Science, Department of
- 19Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 2Pharmacy and Pharmaceutical Sciences, Faculty of
- 2InSciTE & Science 100
- 53Thesis
- 25Article (Published)
- 2Image
- 1Conference/Workshop Poster
- 1Conference/Workshop Presentation
- 1Report
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Fall 2010
Abstract: Introduction: Partial bladder outlet obstruction (pBOO) is a ubiquitous problem that results in renal damage. We hypothesize that change in the bladder progresses over time. Methods: Fischer rats underwent surgical pBOO for 2, 4, 8, or 13 weeks and were compared to shams. Urodynamic...
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2011
Boutin, Hervé, Crossman, David, Smigova, Alison, Drake, Caroline, Allan, Stuart M., Francis, Sheila, Gerhard, Alexander, Jones, Matthew S., Hinz, Rainer, Kassiou, Michael, Hopkins, Stephen J., Vail, Andy, Herholz, Karl, Tyrrell, Pippa J., Selvarajah, Johann R., Rothwell, Nancy J., Julyan, Peter, Georgiou, Rachel F., Brown, Gavin, Maroy, Renaud, Denes, Adam, Russell, James C., Proctor, Spencer D., McColl, Barry W., Prenant, Christian, Hulme, Sharon
Chronic systemic inflammatory conditions, such as atherosclerosis, diabetes and obesity are associated with increased risk of stroke, which suggests that systemic inflammation may contribute to the development of stroke in humans. The hypothesis that systemic inflammation may induce brain...
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Broccoli sprout supplementation during placental insufficiency confers structural and functional neuroprotection to the fetal rat
DownloadSpring 2010
Background: Perinatal ischemic brain injury leads to developmental disability (DD), which accounts for 30% of disabilities in children. Antepartum risk, or risk occurring prior to birth occurs in more than 90% of cases. This study investigated whether maternal ingestion of a natural health...
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Butyrate-mediated genomic changes involved in the non-specific host defenses, matrix remodelling and the immune response in the rumen epithelium of cows afflicted with subacute ruminal acidosis
Download2013
Steele, Michael A., Greenwood, Sabrina L., Plaizier, Jan C., McBride, Brian W., Matthews, James C., Laarman, Anne H., AlZahal, Ousama, Dionissopoulos, Louis
Subacute Ruminal Acidosis (SARA) is a disorder in cattle which can lead to chronic inflammation in the rumen epithelium, known as rumenitis. Butyrate has been shown to attenuate some of the detrimental effects of inflammatory gastroenteral disorders but the molecular mechanisms mediated by...
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Fall 2012
Teleosts rely on innate immunity to protect themselves from pathogens. Colony stimulating factor-1 (CSF-1) and its cognate receptor CSF-1R control survival, proliferation, differentiation and function of macrophages. Recently, a novel soluble form of CSF-1R (sCSF-1R) was identified in goldfish....
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Chemically defined diet alters the protective properties of fructo-oligosaccharides and isomalto-oligosaccharides in HLA-B27 transgenic rats
Download2014
Koleva, Petya, Ketabi, Ali, Dieleman, Levinus A., Gänzle, Michael G., Valcheva, Rosica
Non-digestible oligosaccharides (NDO) were shown to reduce inflammation in experimental colitis, but it remains unclear whether microbiota changes mediate their colitis-modulating effects. This study assessed intestinal microbiota and intestinal inflammation after feeding chemically defined...
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Spring 2011
Niemann-Pick Type C (NPC) disease is an autosomal recessive disorder that results in accumulation of unesterified cholesterol in late endosomes/lysosomes (LE/Ls), leading to progressive neurodegeneration and premature death. Microglia are resident immune cells of the central nervous system, which...
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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Chronic Heart Failure: The Roles of the Tumor Necrosis Factor-Alpha Axis and Left-Atrial Structural and Functional Remodeling
DownloadFall 2014
Heart failure (HF) is a global epidemic, with a substantial burden on healthcare systems. Effective therapies have emerged for patients suffering from HF with reduced ejection fraction (HFREF), but not for those with preserved ejection fraction (HFPEF). Recently, systemic inflammation, driven by...
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Clinical impact of submicroscopic malaria on delivery outcomes and the role of VAR2CSA antibodies in pregnant women from Colombia
DownloadFall 2018
Malaria caused by the genus Plasmodium (P.) is one of the oldest and most important parasitic infections globally. Pregnant women are at an increased risk for malaria, where the disease poses a significant risk to both maternal and child health. Better diagnosis of malaria can have an immediate...