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Skip to Search Results- 4Proctor, Spencer D.
- 4Russell, James C.
- 3Vine, Donna F.
- 2Borthwick, Faye
- 2Hassanali, Zahra
- 2Mangat, Rabban
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Arterial retention of remnant lipoproteins ex-vivo is increased during insulin resistance due to increased arterial biglycan and production of cholesterol-rich atherogenic particles, that can be improved by ezetimibe in the JCR:LA-cp rat
Download2012
Russell, James C., Proctor, Spencer D., Uwiera, Richard R. E., Vine, Donna F., Mangat, Rabban, Hassanali, Zahra, Cheeseman, Christopher I., Borthwick, Faye, Warnakula, Samantha
Background Literature supports the “response-to-retention” hypothesis—that during insulin resistance, impaired metabolism of remnant lipoproteins can contribute to accelerated cardiovascular disease progression. We used the JCR:LA-cp rat model of metabolic syndrome (MetS) to determine the extent...
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2011
Boutin, Hervé, Crossman, David, Smigova, Alison, Drake, Caroline, Allan, Stuart M., Francis, Sheila, Gerhard, Alexander, Jones, Matthew S., Hinz, Rainer, Kassiou, Michael, Hopkins, Stephen J., Vail, Andy, Herholz, Karl, Tyrrell, Pippa J., Selvarajah, Johann R., Rothwell, Nancy J., Julyan, Peter, Georgiou, Rachel F., Brown, Gavin, Maroy, Renaud, Denes, Adam, Russell, James C., Proctor, Spencer D., McColl, Barry W., Prenant, Christian, Hulme, Sharon
Chronic systemic inflammatory conditions, such as atherosclerosis, diabetes and obesity are associated with increased risk of stroke, which suggests that systemic inflammation may contribute to the development of stroke in humans. The hypothesis that systemic inflammation may induce brain...
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Chronic dietary n-3 PUFA intervention improves dyslipidaemia and subsequent cardiovascular complications in the JCR:LA-cp rat model of the metabolic syndrome
Download2011
Borthwick, Faye, Field, Catherine J., Wang, Ye, Proctor, Spencer D., Jaeschke, Anja, Shi, Danni, Hassanali, Zahra, Ruth, Megan, Russell, James C., Mangat, Rabban, Vine, Donna F., Lu, Jing
There is increasing interest in the potential chronic beneficial effects of dietary n-3 PUFA on the metabolic syndrome (MetS) and associated cardiovascular complications. We have recently established that increased dietary n-3 PUFA has a profound acute benefit on fasting lipids and the...
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Down-regulation of hypothalamic pro-opiomelanocortin (POMC) expression after weaning is associated with hyperphagia-induced obesity in JCR rats overexpressing neuropeptide Y
Download2013
Diane, Abdoulaye, Pierce, W. David, Richard, Denis, Heth, C. Donald, Proctor, Spencer D., Vine, Donna F., Russell, James C.
We hypothesised that hypothalamic feeding-related neuropeptides are differentially expressed in obese-prone and lean-prone rats and trigger overeating-induced obesity. To test this hypothesis, in the present study, we measured energy balance and hypothalamic neuropeptide Y (NPY) and...