Characterization of a novel soluble CSF-1 receptor in teleost fish

  • Author / Creator
    Lund, Johanna M
  • Teleosts rely on innate immunity to protect themselves from pathogens. Colony stimulating factor-1 (CSF-1) and its cognate receptor CSF-1R control survival, proliferation, differentiation and function of macrophages. Recently, a novel soluble form of CSF-1R (sCSF-1R) was identified in goldfish. My studies on characterization of sCSF-1R in goldfish and zebrafish assessed the contributions to development and inflammation. In goldfish and zebrafish, sCSF-1R and CSF-1R are not confined to the hematopoietic compartment and show broad expression. The differential expression of these transcripts showcases heterogeneity in immune responses between outbred individuals. Zebrafish sCSF-1R is expressed early in development, suggesting a role during organism and macrophage development. Finally, CSF-1R and sCSF-1R appear to contribute to inflammation, showing expression changes as peritonitis progresses and resolves. My results should contribute to an increased understanding of the regulation of macrophage development and function in teleosts, and allow for characterization of analogous systems in other vertebrate species.

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  • Degree
    Master of Science
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