Search
Skip to Search Results- 17Harding, John C. S.
- 10Plastow, Graham S.
- 6Dekkers, Jack C. M.
- 6Lunney, Joan K.
- 5Ladinig, Andrea
- 4Bao, Hua
- 4Pig
- 3Fetal death
- 3Gene expression
- 3PRRS Virus
- 3PRRSV
- 3Porcine reproductive and respiratory syndrome
-
Novel Resilience Phenotypes Using Feed Intake Data From a Natural Disease Challenge Model in Wean-to-Finish Pigs
Download2019-01-01
Putz, Austin M., Harding, John C. S., Dyck, Michael K., Fortin, F., Plastow, Graham S., Dekkers, Jack C. M., PigGen Canada
The objective of this study was to extract novel phenotypes related to disease resilience using daily feed intake data from growing pigs under a multifactorial natural disease challenge that was designed to mimic a commercial environment with high disease pressure to maximize expression of...
-
Pathologic Evaluation of Type 2 PorcineReproductive and Respiratory SyndromeVirus Infection at the Maternal-FetalInterface of Late Gestation Pregnant Gilts
Download2016-03-10
Novakovic, Predrag, Harding, John C. S., Al-Dissi, Ahmad, Ladinig, Andrea, Detmer, Susan E.
The pathogenesis of fetal death caused by porcine reproductive and respiratory syndromevirus (PRRSV) remains unclear. The objective of this study was to improve our understand-ing of the pathogenesis by assessing potential relationships between specific histopatho-logical lesions and PRRSV RNA...
-
Putting the microbiota to work: Epigenetic effects of early life antibiotic treatment are associated with immune-related pathways and reduced epithelial necrosis following Salmonella Typhimurium challenge in vitro
Download2020-04-01
Costa, Matheus O., Fouhse, Janelle, Silva, Ana Paula P., Wiling, Benjamin, Harding, John C. S.
Salmonella enterica serovar Typhimurium is an animal welfare and public health concern due to its ability to parasite livestock and potentially contaminate pork products. To reduce Salmonella shedding and the risk of pork contamination, antibiotic therapy is used and can contribute to...
-
Relationships of CD163 and CD169 positive cell numbers in the endometrium and fetal placenta with type 2 PRRSV RNA concentration in fetal thymus
Download2016-08-05
Novakovic, Predrag, Harding, John C. S., Ladning, Andrea, Al-Dissi, Ahmad N., MacPhee, Daniel J., Detmer, Susan E.
Several routes of porcine reproductive and respiratory virus PRRSV transmission across the porcine diffuse epitheliochorial placentation have been proposed, but none have been proven. The objectives of this study were to investigate associations between numbers of CD163 and CD169 positive...
-
RESEARCHOpen AccessDevelopment of a 3D printed device tosupport long term intestinal culture as analternative to hyperoxic chamber methods
Download2017-01-01
Costa, Matheus O., Nosach, Roman, Harding, John C. S.
Background:Most interactions between pathogenic microorganisms and their target host occur on mucosal surfaces of internal organs such as the intestine. In vitro organ culture (IVOC) provides an unique tool for studyinghost-pathogen interactions in a controlled environment. However, this...
-
2019-01-01
Lim, Kyu-Sang, Dong, Qian, Moll, Pamela, Vitkovska, Jana, Wiktorin, Gregor, Bannister, Stephanie, Daujotyte, Dalia, Tuggle, Christopher K., Lunney, Joan K., Plastow, Graham S., Dekkers, Jack C. M.
Background:Gene expression profiling in blood is a potential source of biomarkers to evaluate or predict phenotypic differences between pigs but is expensive and inefficient because of the high abundance of globin mRNA in porcine blood. These limitations can be overcome by the use of QuantSeq...
-
The genetic basis of natural antibody titersof young healthy pigs and relationshipswith disease resilience
Download2020-01-01
Chen, Yulu, Tibbs Cortes, Laura E., Ashley, Carolyn, Putz, Austin M., Lim, Kyu-Sang, Dyck, Michael K., Fortin, Frederic, Plastow, Graham S., Dekkers, Jack C. M., Harding, John C. S., PigGen Canada
Background Disease resilience is the ability to maintain performance under pathogen exposure but is difficult to select for because breeding populations are raised under high health. Selection for resilience requires a trait that is heritable, easy to measure on healthy animals, and genetically...
-
Type 2 porcine reproductive and respiratory syndrome virus infection increases apoptosis at the maternal-fetal interface in late gestation pregnant gilts
Download2017-03-01
Novakovic, Predrag, Harding, John C. S., Al-Dissi, Ahmad N., Detmer, Susan E.
The pathogenesis of fetal death associated with porcine reproductive and respiratory syndrome (PRRS) is hypothesized to be a consequence of PRRS virus-induced apoptosis at the maternal-fetal interface (MFI). The objectives of this study were to evaluate distribution and degree of apoptosis in the...