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Skip to Search Results- 1Abou Marak Dit Roum, Darine
- 1Bornes, Troy D.
- 1Chen, Chao
- 1Hayward, Julie A
- 1Ionescu, Lavinia Iuliana
- 1Secretan, Charles Coleman
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Fall 2016
The integration of clinical linear accelerators (linacs) with magnetic resonance imaging (MRI) systems represent the next generation of image guidance technologies in radiotherapy. Linac-MR systems have several potential advantages over the current X-ray based state-of-the-art image guidance...
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Fall 2017
Mesenchymal stem cells (MSCs) have immuno-regulatory, anti-inflammatory, and pro-angiogenic properties through the secretion of a myriad of trophic factors, and have been shown to have a beneficial effect on graft function. In this thesis we investigated whether MSCs’ have an effect on neonatal...
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Spring 2011
The focus of this thesis work was toward advancing our understanding of the normal and pathological development of the diaphragm. This included: (1) studies of the embryology of the primordial diaphragm tissue, the pleuroperitoneal fold (PPF), as it relates to congenital diaphragmatic hernia...
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Effects of macrophages and noggin suppression on the BMP-2-induced osteogenesis of human bone marrow mesenchymal stem cells
DownloadSpring 2011
The osteogenic effects of bone morphogenetic protein-2 (BMP-2) on human mesenchymal stem cells (MSCs) are less profound than expected as compared with rodent cells, and supraphysiological dose of BMP-2 is required to achieve desired clinical outcome. The mechanism for this phenomenon is unclear....
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Fall 2016
Articular cartilage injury is a major risk factor for the development of osteoarthritis, a condition that results in significant patient morbidity and substantial cost to the healthcare system. Due to the limited capacity of articular cartilage to regenerate, early intervention is required to...
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Fall 2021
The menisci are a pair of knee joint structures that are wedge-shaped in cross-section and semi-lunar in superior view. They play roles in force distribution that help maintain the health of the articular cartilage. In adults, the menisci can be divided into a fibrous, vascularized outer region...
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Spring 2013
Type 1 diabetes mellitus (T1DM) is a chronic disorder of glucose metabolism due to autoimmune destruction of insulin producing β-cells. Although insulin therapy is the standard treatment for T1DM, islet transplantation, which has emerged as an alternative to insulin injection, offers a more...
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Spring 2014
The intricate arrangement and composition of articular cartilage confer the structure its unique material and mechanical properties. Degeneration of articular cartilage, especially osteoarthritis, imposes great burden not only on the patients, but also on society. While there exist various...
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Epithelial and vascular progenitors in the developing lung: Newer insights and therapeutic implications
DownloadFall 2012
Stanislaus Alphonse, Anthuvan Rajesh
Bronchopulmonary dysplasia (BPD) and congenital diaphragmatic hernia (CDH) are life-threatening lung diseases affecting newborn infants. Both diseases are characterized by impaired lung development and are currently untreatable. Dysregulation in the number or function of lung progenitor cells is...
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Fall 2012
Recent discoveries in stem cell biology have generated enthusiasm about the possibility of harnessing stem cells for organ repair and regeneration. The ability of pluri- and multipotent stem cells to differentiate along various cellular lineages has placed them at the core of research that seeks...