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Skip to Search Results- 6Graduate and Postdoctoral Studies (GPS), Faculty of
- 6Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 2Agricultural, Food and Nutritional Science, Department of
- 2Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 1Roy Berg Kinsella Research Ranch
- 1Roy Berg Kinsella Research Ranch/Journal Articles (Kinsella Ranch)
- 1Damaraju, Sambasivarao (Medical Sciences - Laboratory Medicine and Pathology)
- 1Dr. Changxi Li (Agricultural, Food & Nutritional Science)
- 1Guan, Leluo (Department of Agricultural, Food, and Nutritional Science, University of Alberta)
- 1Hobman, Tom (Department of Cell Biology)
- 1Lin, Guohui (Computing Science)
- 1Paul Stothard, Department of Agricultural, Food and Nutritional Science
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Transcriptome microRNA profiling of bovine mammary epithelial cells challenged with Escherichia coli or Staphylococcus aureus bacteria reveals pathogen directed microRNA expression profiles
Download2014
Zhao, Xin, Liang, Guanxiang, Jin, Weiwu, Guan, Leluo, Beaudoin, Frédéric, Ibeagha-Awemu, Eveline M.
Background MicroRNAs (miRNAs) can post-transcriptionally regulate gene expression and have been shown to be critical regulators to the fine-tuning of epithelial immune responses. However, the role of miRNAs in bovine responses to E. coli and S. aureus, two mastitis causing pathogens, is not well...
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Fall 2017
In this dissertation, I focus on the study of genotype imputation in population data. Genotype imputation is a process of inferring missing values for genotype data and has been extended to predicting “untyped” genotypes for samples in low-density chips with a reference population assayed using...
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2014
Sargolzaei, M., Li, C., Schenkel, F., Chen, L.
Background Genomic prediction in multiple populations can be viewed as a multi-task learning problem where tasks are to derive prediction equations for each population and multi-task learning property can be improved by sharing information across populations. The goal of this study was to...
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2014
Jin, Weiwu, He, Maolong, Guan, Leluo, Romao, Josue M., McAllister, Tim
Background MicroRNAs (miRNAs) are small non-coding RNAs found to regulate several biological processes including adipogenesis. Understanding adipose tissue regulation is critical for beef cattle as fat is an important determinant of beef quality and nutrient value. This study analyzed the...
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Improving Accuracy of Genomic Prediction for Economically Important Traits in Canadian Holstein Dairy Cattle
DownloadSpring 2017
Milk is a valuable source of energy, high quality protein, and several key minerals and vitamins for humans. Selection for milk production in dairy cattle was first based on phenotype and pedigree information and the knowledge of genetic parameters for the trait of interest. However, substantial...
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Identification of functional genes for feed efficiency traits via transcriptome analyses to enhance the genomic prediction accuracy in beef cattle
DownloadFall 2019
Residual feed intake (RFI), a measure of feed efficiency, and its component traits including average daily gain (ADG), dry matter intake (DMI) and metabolic weight (MWT) are traits of great economic importance to the beef industry. The genetic improvement of these traits can improve the...
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Hsp90 and its co-chaperones regulate the activity of human Argonaute2 in RNA-mediated silencing pathways
DownloadFall 2011
The potent ability of small, double-stranded RNAs to silence gene expression was initially reported 1998, sparking revolutions in molecular biology and genetics. Since then, intensive research into the mechanism of RNA-mediated silencing has implicated the machinery of this pathway in the...
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Genetic and genomic basis of antibody response to porcine reproductive and respiratory syndrome (PRRS) in gilts and sows
Download2016-01-01
Serao, Nick V. L., Kemp, Robert A., Mote, Benny E., Willson, Philip, Harding, John C. S., Bishop, Stephen C., Plastow, Graham S., Dekkers, Jack C. M.
Background:Our recent research showed that antibody response to porcine reproductive and respiratory syn-drome (PRRS), measured as sample-to-positive (S/P) ratio, is highly heritable and has a high genetic correlation with reproductive performance during a PRRS outbreak. Two major quantitative...
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Spring 2014
Adipose tissue plays an important role in the energetic balance, but it is also an important aspect of meat quality and animal productivity. However, the understanding on how fat metabolism is regulated in beef cattle is not clear. This research aimed at exploring how bovine adipose tissue is...
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Drug Resistance in Breast Cancer: Characterization of Rationally Designed Paclitaxel Analogs in Model Systems
DownloadFall 2013
Breast cancer is a leading cause of cancer related deaths among women in the developed world. Treatment options for breast cancer include taxanes, which mediate cytotoxic effects by inducing microtubule polymerization which impedes cell division. Taxane resistant breast cancer is a mounting...