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Skip to Search Results- 9Mesenchymal stem cells
- 7Islet transplantation
- 3Neonatal porcine islets
- 2Articular cartilage
- 2Chondrogenesis
- 2Diabetes
- 1Abou Marak Dit Roum, Darine
- 1Abualhassan, Nasser
- 1Akbari Motlagh, Roozbeh
- 1Arefanian, Hossein
- 1Bornes, Troy D.
- 1Chen, Chao
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Fall 2017
Mesenchymal stem cells (MSCs) have immuno-regulatory, anti-inflammatory, and pro-angiogenic properties through the secretion of a myriad of trophic factors, and have been shown to have a beneficial effect on graft function. In this thesis we investigated whether MSCs’ have an effect on neonatal...
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Fall 2015
The development of the Edmonton protocol was an important milestone in the process of establishing islet transplantation as a cure for diabetes. However, many challenges must still be overcome, including the shortage of donor organs. To address this issue, we believe that neonatal porcine islets...
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Spring 2011
The focus of this thesis work was toward advancing our understanding of the normal and pathological development of the diaphragm. This included: (1) studies of the embryology of the primordial diaphragm tissue, the pleuroperitoneal fold (PPF), as it relates to congenital diaphragmatic hernia...
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Effects of macrophages and noggin suppression on the BMP-2-induced osteogenesis of human bone marrow mesenchymal stem cells
DownloadSpring 2011
The osteogenic effects of bone morphogenetic protein-2 (BMP-2) on human mesenchymal stem cells (MSCs) are less profound than expected as compared with rodent cells, and supraphysiological dose of BMP-2 is required to achieve desired clinical outcome. The mechanism for this phenomenon is unclear....
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Fall 2016
Articular cartilage injury is a major risk factor for the development of osteoarthritis, a condition that results in significant patient morbidity and substantial cost to the healthcare system. Due to the limited capacity of articular cartilage to regenerate, early intervention is required to...
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Fall 2021
The menisci are a pair of knee joint structures that are wedge-shaped in cross-section and semi-lunar in superior view. They play roles in force distribution that help maintain the health of the articular cartilage. In adults, the menisci can be divided into a fibrous, vascularized outer region...
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Fall 2023
Islet transplantation can achieve insulin independence in individuals with type 1 diabetes. However, islets derived from multiple donors are often required, and functional β-cells are lost early after transplantation. Notably, up to 80% of newly transplanted islets are lost due to cell death...
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Spring 2013
Type 1 diabetes mellitus (T1DM) is a chronic disorder of glucose metabolism due to autoimmune destruction of insulin producing β-cells. Although insulin therapy is the standard treatment for T1DM, islet transplantation, which has emerged as an alternative to insulin injection, offers a more...
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Spring 2014
The intricate arrangement and composition of articular cartilage confer the structure its unique material and mechanical properties. Degeneration of articular cartilage, especially osteoarthritis, imposes great burden not only on the patients, but also on society. While there exist various...
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Fall 2012
Recent discoveries in stem cell biology have generated enthusiasm about the possibility of harnessing stem cells for organ repair and regeneration. The ability of pluri- and multipotent stem cells to differentiate along various cellular lineages has placed them at the core of research that seeks...