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Skip to Search Results- 5Vitrification
- 4Articular cartilage
- 4Cryopreservation
- 4Cryoprotectant agents
- 4Viability
- 3Chondrocytes
- 6Chemical and Materials Engineering, Department of
- 6Chemical and Materials Engineering, Department of/Research Articles and Materials (Chemical and Materials Engineering)
- 6Surgery, Department of
- 6Surgery, Department of/Orthopaedic Surgery
- 3Graduate and Postdoctoral Studies (GPS), Faculty of
- 3Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
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2013
Yu, H., Jomha, N. M., Elliott, J. A., Al-Abbasi, K. K., McGann, L. E.
In previous research, we successfully cryopreserved intact human articular cartilage on its bone base with high chondrocyte viability using a vitrification protocol that entailed sequential exposure to several cryopreserving agents (CPAs) at lowering temperatures resulting in a high final...
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2010
Law, G. K., Elliott, J. A., Forbes, J. F., Weiss, A. D., McGann, L. E., Jomha, N. M.
Large articular cartilage defects have proven difficult to treat and often result in osteoarthritis of the affected joint. Cryopreservation of articular cartilage can provide an increased supply of tissues for osteochondral allograft but cryoprotective agents are required; however, few studies...
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2012
Law, G. K., Forbes, J. F., Elliott, J. A., McGann, L. E., Jomha, N. M., Prasad, V., Almansoori, K. A.
Background Vitrification is a method of cryopreservation by which cells and tissues can be preserved at low temperatures using cryoprotective agents (CPAs) at high concentrations (typically ⩾6.0 M) to limit the harmful effects of ice crystals that can form during cooling processes. However, at...
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Determination of Cryoprotectant Behavior, Physiological and Anatomical Characterization of the Porcine Meniscus as a Model for Future Meniscal Vitrification Studies
DownloadSpring 2016
The menisci hold significant, protective biomechanical function in the human knee and loss of meniscal functions have been linked to the development of osteoarthritis. Currently, irreparable or non-salvageable meniscal injuries undergo partial or total removal of injured menisci to alleviate...
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2014
Prasad, V., Laouar, L., Jomha, N. M., McGann, L. E., Fahmy, M. D., Almansoori, K. A., Elliott, J. A.
Vitrification of articular cartilage (AC) could enhance tissue availability but requires high concentrations of cyroprotective agents (CPAs). This study investigated relative injuries caused by commonly used CPAs. We hypothesized that the in situ chondrocyte dose–injury relationships of five...
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Fall 2014
This thesis develops three major essays on Arbitrage Theory, Market’s Viabil- ity and Informational Markets. The first essay (Chapter 3) elaborates the exact connections among the No-Unbounded-Profit-with-Bounded-Risk (called NUPBR hereafter) condition, the existence of the numeraire portfolio,...
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Linking occurrence and fitness to persistence: habitat-based approach for endangered greater sage-grouse
Download2007
Detailed empirical models predicting both species occurrence and fitness across a landscape are necessary to understand processes related to population persistence. Failure to consider both occurrence and fitness may result in incorrect assessments of habitat importance leading to inappropriate...
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Spring 2013
A major barrier to reclamation after oil sands mining is lack of commercially available, diverse native plant seeds and propagules for revegetation. Potential of LFH (forest floor material) developed on coarse textured soil for establishing native plants and how salvage, placement and storage...
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2014-09-26
Rekieh, K., Abazari, A., Elliott, J.A., Jomha, N.M., Law, G.K., McGann, L.E.
Objective: Osteochondral allografting is an effective method to treat large osteochondral defects but difficulties in tissue preservation have significantly limited the application of this technique. Successful cryopreservation of articular cartilage (AC) could improve the clinical availability...
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Statistical prediction of the vitrifiability and glass stability of multi-component cryoprotective agent solutions.
Download2010
Forbes, J. F., Law, G. K., Weiss, A. D., Scheuerman, A., McGann, L. E., Elliott, J. A., Jomha, N. M.
Long-term biologic storage of articular cartilage has proven elusive due to cellular degradation over time or acute damage during attempts at cryopreservation. Vitrification is one option that may result in successful cryopreservation but difficulty with cryoprotective agent (CPA) toxicity at...