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Metabolism of vertebrate amino sugars with N-glycolyl groups: Intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc,and the biochemical and structural rationale for the substrate tolerance of β-O-linked& beta;-N-acetylglucosaminidase
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Vocadlo, David J. , Chan, Jefferson, Whitworth, Garrett A., Macauley, Matthew S., Stubbs, Keith A., Varki, Ajit, Davies, Gideon J., Yuzwa, Scott, Zandberg, Wesley, Bennet, Andrew J., He, Yuan
The O-GlcNAc modification involves the attachment of single β-O-linked N-acetylglucosamine residues to serine and threonine residues of nucleocytoplasmic proteins. Interestingly, previous biochemical and structural studies have shown that O-GlcNAcase (OGA), the enzyme that removes O-GlcNAc from...
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Weak tradeoff between xylem safety and xylemspecific hydraulic efficiency across the world’s woody plant species
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Maherali, H., Cao, K-.F., Schreiber, S.G., Brodribb, T.J., Westoby, M., Hacke, U.G., Jacobsen, A.L., Lens, F., Choat, B., Wright, I.J., Pittermann, J., Gleason, S., Bhaskar, R., Nardini, A., Morris, H., Mayr, S., Bucci, S.J., Mencuccini, M., Johnson, D.M., Mitchell, P.J., Fan, Z-.X., Sperry, J.S., Delzon, S., Zanne, A.E., Martínez-Vilalta, J., Cochard, H., Plavcová, L., McCulloh, K.A., Jansen, S., Domec, J-.C., Pratt, R.B., Feild, T.S.
The evolution of lignified xylem allowed for the efficient transport of water under tension, but also exposed the vascular network to the risk of gas emboli and the spread of gas between xylem conduits, thus impeding sap transport to the leaves. A well-known hypothesis proposes that the safety of...