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Skip to Search Results- 4He, Yuan
- 3Macauley, Matthew S.
- 2Arlian, Britni M.
- 2McBride, Ryan
- 1Bennet, Andrew J.
- 1Chan, Jefferson
- 2Glycobiology
- 2Sialic Acid
- 1Alzheimers-Disease
- 1Antigen; Binding
- 1Capillary Electrophoresis
- 1Carbohydrate Biosynthesis
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Disubstituted sialic acid ligands targeting siglecs CD33 and CD22 associated with myeloid leukaemias and B cell lymphomas
Download2014
McBride, Ryan, Fokin, Valery V., He, Yuan, Macauley, Matthew S., Paulson, James C. , Arlian, Britni M., Rillahan, Cory D., Rangarajan, Janani, Schwartz, Erik
The siglec family of sialic acid-binding proteins are endocytic immune cell receptors that are recognized as potential targets for cell directed therapies. CD33 and CD22 are prototypical members and are validated candidates for targeting acute myeloid leukaemia and non-Hodgkin's lymphomas due to...
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Macromolecular Engineering towards the Fabrication of Biomimetic Membranes with Water Channel Proteins for Desalination Applications
DownloadFall 2016
Due to the fast development of human society and high growth of world population, fresh water shortage has become one of the most critical and urgent problems of our society. Since the discovery of aquaporins (water channel proteins), researchers have been trying to incorporate them as functional...
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Metabolism of vertebrate amino sugars with N-glycolyl groups: Intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc,and the biochemical and structural rationale for the substrate tolerance of β-O-linked& beta;-N-acetylglucosaminidase
Download2012
Vocadlo, David J. , Chan, Jefferson, Whitworth, Garrett A., Macauley, Matthew S., Stubbs, Keith A., Varki, Ajit, Davies, Gideon J., Yuzwa, Scott, Zandberg, Wesley, Bennet, Andrew J., He, Yuan
The O-GlcNAc modification involves the attachment of single β-O-linked N-acetylglucosamine residues to serine and threonine residues of nucleocytoplasmic proteins. Interestingly, previous biochemical and structural studies have shown that O-GlcNAcase (OGA), the enzyme that removes O-GlcNAc from...
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Unmasking of CD22 on germinal center B-cells occurs by alternative mechanisms in mouse and man
Download2015
McBride, Ryan, Wang, Shui-Hua , Macauley, Matthew S., Khoo, Kay-Hooi, Paulson, James C., Kannagi, Reiji, Peng, Wenjie, He, Yuan, Kawasaki, Norihito, Arlian, Britni M.
CD22 is an inhibitory B-cell co-receptor whose function is modulated by sialic acid (Sia)-bearing glycan ligands. Glycan remodeling in the germinal center (GC) alters CD22 ligands, with as yet no ascribed biological consequence. Here, we show in both mice and humans that loss of high affinity...