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Spring 2023
Hyaline cartilage is a strong and flexible connective tissue found throughout the human body. It provides important structural and functional support for the nose, ribs, larynx, and trachea. Due to the avascular nature of the hyaline cartilage, its defects or lesions are non-regeneratable and...
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Computational support systems for prediction and characterization of protein crystallization outcomes
DownloadFall 2013
Analysis of protein structures may reveal their function, regulation and interactions. Almost 90% of the known protein structures were solved using X-ray crystallography; however, many more structures remain unsolved. Protein Structure Initiative (PSI) project was created to speed up structure...
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2010
Law, G. K., Elliott, J. A., Forbes, J. F., Weiss, A. D., McGann, L. E., Jomha, N. M.
Large articular cartilage defects have proven difficult to treat and often result in osteoarthritis of the affected joint. Cryopreservation of articular cartilage can provide an increased supply of tissues for osteochondral allograft but cryoprotective agents are required; however, few studies...
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2012
Law, G. K., Forbes, J. F., Elliott, J. A., McGann, L. E., Jomha, N. M., Prasad, V., Almansoori, K. A.
Background Vitrification is a method of cryopreservation by which cells and tissues can be preserved at low temperatures using cryoprotective agents (CPAs) at high concentrations (typically ⩾6.0 M) to limit the harmful effects of ice crystals that can form during cooling processes. However, at...
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Determination of Cryoprotectant Behavior, Physiological and Anatomical Characterization of the Porcine Meniscus as a Model for Future Meniscal Vitrification Studies
DownloadSpring 2016
The menisci hold significant, protective biomechanical function in the human knee and loss of meniscal functions have been linked to the development of osteoarthritis. Currently, irreparable or non-salvageable meniscal injuries undergo partial or total removal of injured menisci to alleviate...
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Fall 2011
Metabolomics aims to study all small-molecule compounds (i.e. metabolites) in cells, tissues, or biofluids. These compounds provide a functional readout of the physiological, developmental, and pathological state of a biological system. The field of metabolomics has expanded rapidly over the last...
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2014
Prasad, V., Laouar, L., Jomha, N. M., McGann, L. E., Fahmy, M. D., Almansoori, K. A., Elliott, J. A.
Vitrification of articular cartilage (AC) could enhance tissue availability but requires high concentrations of cyroprotective agents (CPAs). This study investigated relative injuries caused by commonly used CPAs. We hypothesized that the in situ chondrocyte dose–injury relationships of five...
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Finite Element Model of the Thermal Profile During Submerged Arc Welding with One and Two Electrodes
DownloadFall 2016
The submerged-arc welding (SAW) process is used extensively in the manufacturing of pipes. The heat flow introduced by the welding operation has a significant impact on the properties of both the weld metal and the heat affected zone (HAZ). The work presented in this thesis aims to develop a...
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John B. Smith Archive - Chronological Bibliography Bundle 1 (Books, Monographs, Separately Bound Publications)
John B. Smith Archive - Chronological Bibliography Bundle 1 (Books, Monographs, Separately Bound Publications)
Download1980, 1981, 1994
A bundle of the long-form works of John B. Smith, provided by John B. Smith from his personal collection. This collection encompasses a book, a monograph, and a separately bound technical report. The book is a formally published edition of his PhD dissertation, \"Imagery and the Mind of Stephen...
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John B. Smith Archive - Chronological Bibliography Bundle 2 (Articles, Chapters, Conference Papers)
John B. Smith Archive - Chronological Bibliography Bundle 2 (Articles, Chapters, Conference Papers)
Download1971-1993
A bundle of the short-form works of John B. Smith, provided by John B. Smith from his personal collection. This collection encompasses Smith's short form publications, including articles, book chapters and conference proceedings. It spans a wide range of research interests, from computer-assisted...