Journal Articles

2020-10-11

Amat, Samat, Lantz, Hannah, Munyaka, Peris M., Willing, Benjamin P.

A diverse and dynamic microbial community (known as microbiota) resides within the pig gastrointestinal tract (GIT). The microbiota contributes to host health and performance by mediating nutrient metabolism, stimulating the immune system, and providing colonization resistance against pathogens....

2017-01-01

Goddard, Ellen, Hartmann, Monika, Klink-Lehmann, Jeanette

The use of antibiotics in livestock production has repeatedly been in the dock over the last few years. However, reducing antibiotic treatments without increasing the suffering of animals requires changes in animal husbandry practices which will likely come at a cost. The objective of the paper...

2020-04-01

Costa, Matheus O., Fouhse, Janelle, Silva, Ana Paula P., Wiling, Benjamin, Harding, John C. S.

Salmonella enterica serovar Typhimurium is an animal welfare and public health concern due to its ability to parasite livestock and potentially contaminate pork products. To reduce Salmonella shedding and the risk of pork contamination, antibiotic therapy is used and can contribute to...

2016-08-05

Novakovic, Predrag, Harding, John C. S., Ladning, Andrea, Al-Dissi, Ahmad N., MacPhee, Daniel J., Detmer, Susan E.

Several routes of porcine reproductive and respiratory virus PRRSV transmission across the porcine diffuse epitheliochorial placentation have been proposed, but none have been proven. The objectives of this study were to investigate associations between numbers of CD163 and CD169 positive...

2017-01-01

Costa, Matheus O., Nosach, Roman, Harding, John C. S.

Background:Most interactions between pathogenic microorganisms and their target host occur on mucosal surfaces of internal organs such as the intestine. In vitro organ culture (IVOC) provides an unique tool for studyinghost-pathogen interactions in a controlled environment. However, this...

2018-01-01

Walker, Lianna R., Engle, Taylor B., Vu, Hiep, Tosky, Emily R., Nonneman, Dan J., Smith, Timothy P. L., Borza, Tudor, Burkey, Thomas E., Plastow, Graham S., Kachman, Stephen D., Ciobanu, Daniel C.

Porcine circovirus 2 (PCV2) is a circular single-stranded DNA virus responsible for a group of diseases collectively known as PCV2 Associated Diseases (PCVAD). Variation in the incidence and severity of PCVAD exists between pigs suggesting a host genetic component involved in pathogenesis. A...

2019-01-01

Lim, Kyu-Sang, Dong, Qian, Moll, Pamela, Vitkovska, Jana, Wiktorin, Gregor, Bannister, Stephanie, Daujotyte, Dalia, Tuggle, Christopher K., Lunney, Joan K., Plastow, Graham S., Dekkers, Jack C. M.

Background:Gene expression profiling in blood is a potential source of biomarkers to evaluate or predict phenotypic differences between pigs but is expensive and inefficient because of the high abundance of globin mRNA in porcine blood. These limitations can be overcome by the use of QuantSeq...

2020-01-01

Chen, Yulu, Tibbs Cortes, Laura E., Ashley, Carolyn, Putz, Austin M., Lim, Kyu-Sang, Dyck, Michael K., Fortin, Frederic, Plastow, Graham S., Dekkers, Jack C. M., Harding, John C. S., PigGen Canada

Background Disease resilience is the ability to maintain performance under pathogen exposure but is difficult to select for because breeding populations are raised under high health. Selection for resilience requires a trait that is heritable, easy to measure on healthy animals, and genetically...

2017-03-01

Novakovic, Predrag, Harding, John C. S., Al-Dissi, Ahmad N., Detmer, Susan E.

The pathogenesis of fetal death associated with porcine reproductive and respiratory syndrome (PRRS) is hypothesized to be a consequence of PRRS virus-induced apoptosis at the maternal-fetal interface (MFI). The objectives of this study were to evaluate distribution and degree of apoptosis in the...