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Influence of forest canopies on the deposition of methylmercury to boreal ecosystem watersheds
DownloadFall 2010
Methylmercury (MeHg) is a potent vertebrate neurotoxin and a contaminant of global concern. Increased anthropogenic emissions of mercury (Hg) to the atmosphere have led to increased bioaccumulation of MeHg in top predatory organisms such as fish, the consumption of which is the main exposure...
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Influence of lipids (arachidonic acid and cholesterol) on calcium signalling in rodent pancreatic beta cells
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Ca2+ is an important mediator of stimulus-secretion coupling in beta cells of the pancreatic islets, which secrete insulin in response to elevation in plasma glucose concentration. I studied the actions of two lipids, arachidonic acid (AA) and cholesterol, on enzymatically-dissociated single...
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Information hippies, Google-fu masters, and other volunteer tourists in Thailand: information behaviour in the liminoid
DownloadSpring 2010
Using social positioning theory and the concept of the liminoid, the objectives of this qualitative research project were three-fold: 1) investigate how social positioning affects the information behaviour of volunteer tourists; 2) determine what effects cultural confusion (aka “culture shock”),...
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Fall 2010
Peroxisomes are indispensable organelles that perform many essential metabolic activities. Thus, eukaryotic cells have evolved molecular mechanisms to ensure the inheritance of peroxisomes from mother cell to daughter cell at cell division. In the budding yeast Saccharomyces cerevisiae, the class...
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Initial adhesion of EPS producing bacteria Burkholderia cepacia – the impact of cranberry juice
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The impact of cranberry juice was investigated with respect to the initial adhesion of three isogenic Burkholderia cepacia bacteria with different extracellular polymeric substance (EPS) producing capacities: a wild-type cepacian EPS producer PC184, mutant bacteria PC184rml with reduced EPS...
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Spring 2010
Intercropping systems offer potential benefits relative to monocultures of increased crop yields and improved pest control through physical, chemical, or behavioural interference and the enhancement of natural enemy populations, prompting increased predation and parasitism. Intercrops of canola...
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Insights into the Transcriptional Regulation and Physiological Importance of Phosphatidylethanolamine N-Methyltransferase
DownloadSpring 2010
Phosphatidylcholine (PC) is made in all nucleated mammalian cells via the CDP-choline pathway. Another major pathway for PC biosynthesis in liver is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). We have identified 3T3-L1 adipocytes as a cell culture model that expresses PEMT...
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Fall 2010
This thesis encompasses the development and testing of an interstitial photodynamic therapy (iPDT) system for the treatment of prostate cancer. It begins with the optical characterization of a novel photosensitizer (SL-052) followed by a study of tissue optics as it applies to iPDT. The design...
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Insulin signaling, mitochondrial DNA copy number regulation and aging in Caenorhabditis elegans
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Mitochondrial dysfunction is considered as a key mechanism of aging but little is known about the impact of mitochondrial biogenesis. Mitochondrial DNA (mtDNA) copy number control is an important aspect of mitochondrial biogenesis and is highly regulated in eukaryotic organisms. By studying mtDNA...
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Integrated pest management of Sitona lineatus L. (Coleoptera: Curculionidae) in crops of Pisum sativum L. (Fabales: Fabaceae) in Western Canada
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Sitona lineatus L. (Coleoptera: Curculionidae) is a pest of Pisum sativum L. (Fabales: Fabaceae) and managing it is a challenge because of its fecundity, migratory behavior and concealed larval habitat. Potential components of an integrated pest management program for S. lineatus were...