Instrumentation for Interstitial Photodynamic Therapy of Prostatic Carcinoma

• Author / Creator

  Liu, Weiyang

• This thesis encompasses the development and testing of an interstitial photodynamic therapy (iPDT) system for the treatment of prostate cancer. It begins with the optical characterization of a novel photosensitizer (SL-052) followed by a study of tissue optics as it applies to iPDT. The design and integration of a time-fractionated light delivery system with real-time spectral detection is then examined. An optical phantom test medium is formulated and in vitro system operation and testing is performed. Finally, in vivo experiments are performed on animal models with a focus on canine prostate iPDT. Unique optical results with dosimetric relevance are discovered and investigated. This includes metrics for optically measuring local in vivo SL-052 concentrations in real-time as well as novel oscillatory drug photobleaching and recovery behavior during time-fractionated light delivery.

• Subjects / Keywords

  • Real-Time Monitoring
  • PDT
  • Photodynamic Therapy
  • Intra-Arterial
  • Interstitial
  • Switched Delivery
  • Pulsed Delivery
  • SL-052
  • Oscillations
  • Porstate Cancer
  • Fractionated Light Delivery
  • Dosimetry
  • Spectral Detection
  • Hypocrellin

• Graduation date

  Fall 2010

• Type of Item

  Thesis

• Degree

  Master of Science

• DOI

  https://doi.org/10.7939/R34050

• License

  This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.