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Herpes Simplex Virus Requires VP11/12 to Activate Src Family Kinase-PI3 Kinase-Akt Signalling
DownloadFall 2010
This thesis defines a novel role for the Herpes Simplex Virus (HSV) tegument protein, virion protein (VP) 11/12 as a modulator of host cell signalling. Studies aimed at examining infection induced lymphocyte inactivation, revealed that VP11/12 is tyrosine phosphorylated in three lymphocyte...
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High levels of green-tree retention are required to preserve ground beetle biodiversity in boreal mixedwood forests
Download2010
Jacobs, J.J., Volney, W.J.A., Work, T.T., Spence, J.R.
Recovery of biodiversity and other ecosystem functions to pre-disturbance levels is a central goal of natural disturbance-based approaches to ecosystem management. In boreal mixedwood forests, green-tree retention has been proposed as an alternative approach to traditional clearcutting that may...
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High performance live migration over low-bandwidth, high-delay network with loss prevention
DownloadFall 2010
Virtualization technology has attracted considerable interest. It allows several virtual machines to run concurrently inside a physical host, which brings multiple advantages. One of the most useful features is called live migration, during which a virtual machine can be migrated over network...
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High resolution mapping of community structure in three glass sponge reefs (Porifera, Hexactinellida)
Download2010
Glass sponge reefs (Porifera, Hexactinellida) are unique to the Pacific coast of Canada. To date, the locations and extents of reefs have only been assessed by multibeam echosounders, a method that does not resolve where live, dead and buried sponges are within a reef. We performed fine-scale (25...
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High resolution optical tweezers for single molecule studies of hierarchical folding in the pbuE riboswitch aptamer
DownloadSpring 2010
Riboswitches are gene regulatory elements found in messenger RNA that function by changing structure upon the binding of a ligand to an aptamer domain. Single adenine-binding pbuE riboswitch aptamer RNAs were unfolded and refolded co-transcriptionally using optical tweezers for single molecule...
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Fall 2010
We have developed several generations of high voltage (HV) integrated circuits that provide micro-scale platforms for lab-on-a-chip applications. This thesis presents novel HV devices and circuits that lead to further miniaturization and minimize the dependence on off-chip components. A...
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High-dimensional data mining: subspace clustering, outlier detection and applications to classification
DownloadSpring 2010
Data mining in high dimensionality almost inevitably faces the consequences of increasing sparsity and declining differentiation between points. This is problematic because we usually exploit these differences for approaches such as clustering and outlier detection. In addition, the exponentially...
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2010
Siloto, Rodrigo M. P., Weselake, Randall J.
Neutral lipids are ubiquitously found in nature, serving primarily as energy storage compounds. The ability to control the rate of neutral lipid bioassembly is of particular interest in numerous applications. For example, restriction of triacylglycerol and steryl ester synthesis in mammals could...
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Fall 2010
This thesis summarizes a study of higher-dimensional distorted objects such as a distorted 5-dimensional Schwarzschild-Tangherlini black hole. It considers a particular type of distortion corresponding to an external, static distribution of matter and fields around this object. The corresponding...