Search

Fall 2013

Chow, Aaron K.Y.

We developed a small animal model of pure antibody-mediated rejection (ABMR) by utilizing fully major histocompatibility complex (MHC) mismatched kidney allografts in mice. By examining resultant ABMR pathology, we show that terminal complement products C5a and C5b-9 are crucial in establishing...

Fall 2012

Boyd, Jessica M.

Disinfection byproducts (DBPs) are an unwanted consequence of water disinfection. Consumption of chlorinated drinking water has been associated with an increased risk of bladder cancer; however, the DBP or DBPs responsible has not been identified. The N-nitrosamines are a class of DBPs that are...

Spring 2016

Wang, Wei

Water disinfection is necessary for killing pathogens, but it causes an unintended chemical risk from the formation of disinfection byproducts (DBPs). Epidemiological studies show a potential association of water disinfection with increased risk of bladder cancer. It is unknown what DBPs are...

Spring 2016

Basonbul, Asmaa A

There is evidence that the symptoms associated with sickle cell disease can be relieved by using plant extracts containing anthocyanin (AC) agents. It has been established that ACs were able to reverse sickle cell morphology to a biconcave disc shape. However, no specific form of AC has been...

Fall 2010

Chakravarthy Sridharan, Malinee

Breast cancer is a heterogeneous, polygenic disease and is influenced by genetic, environmental and life-style factors. Many single nucleotide polymorphisms (SNPs) associated with breast cancer risk have been identified in genome-wide association studies (GWASs) by several research groups for...

Fall 2009

Samadi, Nasser

First-line treatment of breast and other cancers with Taxol is compromised by resistance in up to 40% of patients. To improve chemotherapy, it is vital to understand how Taxol resistance develops and to overcome this. Autotaxin (ATX) promotes cancer cell survival, growth, migration, invasion...

Fall 2013

Moe, Birget K

We demonstrate the development of a real-time cell analysis (RTCA) platform for studying nanoparticle- and arsenic-induced cytotoxicity with potential applications to risk assessment, environmental toxicity monitoring, and drug development. RTCA is an impedance-based in vitro detection system...

Fall 2009

Ross-Rodriguez, Lisa Ula

Recent advances in the fundamental theories in cryobiology using thermodynamic principles have created new opportunities for innovative methodologies in cryobiology. This thesis tested the hypothesis that calculated indicators of the two-factor hypothesis of cryoinjury, depending on cellular...

Fall 2016

Hasing Rodriguez, Maria E

Norovirus (NoV) is recognized as the leading agent causing gastroenteritis among individuals of all ages. Historical data of NoV outbreak surveillance in Alberta, Canada, from the period July 2000 to June 2008 demonstrated a biennial pattern of NoV outbreak activity, in which peaks of high...

Spring 2012

Boone, Tyler J

Group B streptococcus (GBS) is a major cause of invasive disease in the neonatal and adult populations. To mediate invasive disease, GBS encodes a variety of surface expressed and secreted components. One surface expressed protein that may contribute to GBS virulence is phosphoglycerate kinase...