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- 1Abou Zeinab, Rami M
- 1Abuetabh, Yasser H
- 1Albahrani, Redha Mohammed
- 1Allen,Richelle J
- 1Almizraq, Ruqayyah J
- 1Alshareef, Abdulraheem
Results for "departments_tesim:"Medical Sciences- Laboratory Medicine and Pathology""
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase receptor that was initially identified as a potent oncogenic driver in anaplastic large-cell lymphoma (ALCL) in the form of NPM-ALK fusion protein. Various forms of oncogenic ALK proteins have been identified, subsequently, in various...
Delineation of Molecular Mechanisms Underlying the Pathobiology of ALK-positive Anaplastic Large-cell LymphomaDownload
ALK-positive anaplastic large-cell lymphoma (ALK+ALCL) is a rare type non-Hodgkin lymphoma of null/T cell original, preferentially occurs in children and young adults. Approximately 85% of ALK+ALCL patients carry the gene translocation t(2;5)(p23;q35), which results in the generation of the...
The p53 family of tumor suppressors is an important group of transcription factors preventing the development of cancer by targeting cell-cycle arrest and apoptosis mediator proteins for transcription. The most studied, p53, is frequently inactivated in carcinomas by mutation or genetic...
A phenylarsenical, 3-nitro-4-hydroxyphenylarsonic acid (RoxarsoneÂ®, Rox), has been used extensively as a poultry feed additive for over 60 years. However, little is known about the concentrations of different arsenic species present in chicken meat as a consequence of feeding Rox to chickens....
Breast cancer is the most common cancer among women in the developed world. The disease results from the combined effects of genetic, environmental, reproductive and lifestyle risk factors. Germline DNA variations identified thus far by linkage and genome-wide association studies (GWASs) account...
Reoviruses have been shown to infect a very broad range of mammalian sources and infections in humans have been associated with gastrointestinal and respiratory illnesses. While the presence of reovirus in several different water matrices and clinical samples has been reported, the clinical...
Identifying and Characterizing Red Blood Cell Microvesiculation, Phosphatidylserine and CD47 Expression As a Predictor of Red Blood Cell In Vitro Quality Following Hypothermic StorageDownload
Abstract: Proper preservation of the quality of stored red blood cells (RBC) is fundamental for successful blood transfusion. RBC microparticles (RMPs) have been shown to be harmful effectors of inflammation and coagulation posttransfusion, as well as in vitro indicators of RBC function and...
Disinfection byproducts (DBPs) are an unwanted consequence of water disinfection. Consumption of chlorinated drinking water has been associated with an increased risk of bladder cancer; however, the DBP or DBPs responsible has not been identified. The N-nitrosamines are a class of DBPs that are...
Perfluoroalkyl acids (PFAAs) are a family of emerging toxicants that are non-biodegradable, and have the potential to bioconcentrate and biomagnify. In an attempt to answer questions about human exposure to PFAAs, and subsequent human disposition of these compounds which have public health...
Candida albicans is an opportunistic pathogen and major cause of invasive fungal infections. Choice of antifungal therapy is complicated by the underlying associated diseases of patients infected, other drug interactions, and in vitro susceptibility of the isolate. Echinocandins are emerging as a...