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- 144Chemistry, Department of/Journal Articles (Chemistry)
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- 69Klassen, John S.
- 52Kitova, Elena N.
- 17Serpe, Michael J.
- 13Macauley, Matthew S.
- 12Liu, Lan
- 10El-Hawiet, Amr
- 20Electrospray ionization mass spectrometry
- 12Affinity
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Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation
2014
Macauley, M. S., Cheng, T. Y., Moody, D. B., Paulson, J. C. , Kawasaki, N., Van Rhijn, I., Rillahan, C. D.
Lipids from mycobacteria can be presented to human T cells by group 1 CD1 Ag-presenting molecules (CD1a, CD1b, and CD1c). Group 1 CD1-restricted T cells are activated by lipid Ags presented by myeloid dendritic cells (DCs), after which they generate antibacterial effector functions, including...
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2016
O’Dwyer, Michael E., Macauley, Matthew S., Natoni, Alessandro
Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids has been linked to increased immune cell evasion, drug evasion, drug resistance, tumor invasiveness, and...
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2022-01-01
Cyclic tetraaryl[5]cumulenes (1a–f) have been synthesized and studied as a function of increasing ring strain. The magnitude of ring strain is approximated by the extent of bending of the cumulenic core as assessed by a combination of X-ray crystallographic analysis and DFT calculations. Trends...
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The influence of temperature on the pyrolysis of household products
2016-01-01
Xiao Qin Lee, P. Mark L. Sandercock, James J. Harynuk
We have previously demonstrated the successful application of multivariate statistical(i.e. chemometric) techniques to the classification of casework fire debris based on gasoline content, with the objective to expedite the data interpretation process for the forensic analysis of fire debris. We...
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Thermal dissociation of streptavidin homotetramer in the gas phase: Subunit loss versus backbone fragmentation
Download2013
Deng, Lu, Klassen, John S., Kitova, Elena N., Sinelnikov, Igor
The results of time-resolved blackbody infrared radiative dissociation experiments performed on gaseous protonated ions, at charge states +15, +16 and +17, of the homotetramer streptavidin (S4) are reported. Evidence is found for three dissociation pathways involving (i) the loss of a single...
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Thermal dissociation of streptavidin homotetramer in the gas phase: Subunit loss versus backbone fragmentation
Download2013
Klassen, John S., Sinelnikov, Igor, Kitova, Elena N., Deng, Lu
The results of time-resolved blackbody infrared radiative dissociation experiments performed on gaseous protonated ions, at charge states +15, +16 and +17, of the homotetramer streptavidin (S4) are reported. Evidence is found for three dissociation pathways involving (i) the loss of a single...
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2015
Xiao, Changchun., Gonzalez-Martin, Alicia, Miletic, Ana V., Rickert, Robert C., Head, Steven R., Knight, Sarah, , Macauley, Matthew S., Lai, Maoyi, Jin, Hyun Y., Sabouri-Ghomi, Mohsen
Transient transfection of chemically synthesized microRNA (miRNA) mimics is being used extensively to study the functions and mechanisms of endogenous miRNAs. However, it remains unclear whether transfected miRNAs behave similarly to endogenous miRNAs. Here we show that transient transfection of...
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2015
Zhong, Weiming, Quigley, Christina, Klassen, John S., Fang, Hao, Jiang, Xi, Wei, Chao, Tan, Ming, Xia, Ming, Huang, Pengwei, Fan, Qiang, Zhang, Xufu
The recent discovery that human noroviruses (huNoVs) recognize sialic acids (SAs) in addition to histo-blood group antigens (HBGAs) pointed to a new direction in studying virus-host interactions during calicivirus infection. HuNoVs remain difficult to study due to the lack of an effective cell...
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Unique Ion Filter: A data reduction tool for GC/MS data preprocessing prior to chemometric analysis
Download2014
Harynuk, James, Adutwum, Lawrence A.
Using raw GC/MS data as the X-block for chemometric modeling has the potential to provide better classification models for complex samples when compared to using the total ion current (TIC), extracted ion chromatograms/profiles (EIC/EIP), or integrated peak tables. However, the abundance of raw...
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Unmasking of CD22 on germinal center B-cells occurs by alternative mechanisms in mouse and man
Download2015
McBride, Ryan, Wang, Shui-Hua , Macauley, Matthew S., Khoo, Kay-Hooi, Paulson, James C., Kannagi, Reiji, Peng, Wenjie, He, Yuan, Kawasaki, Norihito, Arlian, Britni M.
CD22 is an inhibitory B-cell co-receptor whose function is modulated by sialic acid (Sia)-bearing glycan ligands. Glycan remodeling in the germinal center (GC) alters CD22 ligands, with as yet no ascribed biological consequence. Here, we show in both mice and humans that loss of high affinity...