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Fall 2019
Vega Mesquida, Ileana Magdalena
The rise in motor vehicle ownership has become not only an environmental issue, but also a public health threat as pollutants emitted negatively affect human health (Deng et al., 2017). One such pollutant is particulate matter, which has been regulated by a variety of countries because it...
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2002-01-01
Li, Xiuju J., Alvarez, Bernando, Casey, Joseph R., Reithmeier, Reinhart A. F., Fliegel, Larry
We examined the ability of carbonic anhydrase II to bind to and affect the transport efficiency of the NHE1 isoform of the mammalian Na+/H+ exchanger. The C-terminal region of NHE1 was expressed in Escherichia coli fused with an N-terminal glutathionineS-transferase or with a C-terminal...
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Spring 2014
Ichnology concerns the study of interactions between organisms and both soft and hard substrates. Actualistic observation of a modern day river channel molluscan assemblage including unionid and sphaeriid bivalves and gastropods within the Saint John River, Fredericton, New Brunswick, Canada...
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Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the na+/H+ exchanger
Download2005-01-01
Slepkov, Emily R., Rainey, Jan K., Li, Xiuju J., Liu, Yonghsheng S., Cheng, Florence J., Lindhout, Darrin A., Sykes, Brian D., Fliegel, Larry
The Na+/H+ exchanger isoform 1 is a ubiquitously expressed integral membrane protein that regulates intracellular pH in mammals. We characterized the structural and functional aspects of the critical transmembrane (TM) segment IV. Each residue was mutated to cysteine in cysteine-less NHE1. TM IV...
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Structural and functional characterization of transmembrane segment IX of the NHE1 isoform of the na(+)/H(+) exchanger
Download2008-01-01
Reddy, Tyler, Ding, Jie, Li, Xiuju J., Sykes, Brian D., Rainey, Jan K., Fliegel, Larry
The Na+/H+ exchanger isoform 1 (NHE1) is an integral membrane protein that regulates intracellular pH by removing one intracellular H+ in exchange for one extracellular Na+. It has a large N-terminal membrane domain of 12 transmembrane segments and an intracellular C-terminal regulatory domain....
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Fall 2018
Chloride intracellular channel (CLIC) proteins comprise six members CLIC1–CLIC6 in mammals and mediate functions not fully known. Their founding member was isolated from bovine kidney using the chloride channel inhibitor indanyloxyacetic acid-94, so CLICs were assumed to be typical anion...