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- 4Force spectroscopy
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- 7Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
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- 1Physics, Department of/Journal Articles (Physics)
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Atomic Force Microscopy Characterization of Hydrogen Terminated Silicon (100) 2x1 Reconstruction
DownloadFall 2015
Non-contact Atomic Force Microscopy (NC-AFM) is a Scanning Probe Microscopy tool offering unique non-perturbative analysis of surfaces and adsorbates at the atomic scale. AFM precisely oscillates a sharp tip above a sample. By monitoring the shift in resonance frequency of a quartz tuning fork...
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2021-10-01
Petrosyan, Rafayel, Narayan, Abhishek, Woodside, Michael T
The use of force probes to induce unfolding and refolding of single molecules through the application of mechanical tension, known as single-molecule force spectroscopy (SMFS), has proven to be a powerful tool for studying the dynamics of protein folding. Here we provide an overview of what has...
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Fall 2013
Protein folding involves a stochastic search through the configurational energy landscape towards the native structure. Although most proteins have evolved to fold efficiently into a unique native structure, misfolding (the formation of non-native structures) occurs frequently in vivo causing a...
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Spring 2017
Prion diseases, are associated with the misfolded form of the prion protein (PrPSc). The prion protein (PrP) has a unique means of transferring infectious diseases, based on a misfolded conformation. However, the mechanism of formation of PrPSc remains unclear owing to difficulties in defining...
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Studying the effects of mouse prion protein on mice and rat colon antibacterial gene expression profiling
DownloadFall 2013
The objectives of this thesis research are: 1) to evaluate whether there is interspecies translocation of mouse recombinant prion protein (moPrP) through colon tissue of rats; 2) to investigate whether lipopoplysaccharide (LPS) from Escherichia coli influences permeability of moPrP through the...
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Fall 2017
The formation of an abnormal form of proteins in cells can cause aggregation and neurodegenerative pathology, such as Alzheimer’s, Parkinson’s and prion diseases, which affects both humans and animals. Nowadays, the understanding of the mechanism of prion misfolding and propagation, including...
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Ultraviolet-ozone treatment reduces levels of disease-associated prion protein and prion infectivity
Download2009
Gilbert, P., Pedersen, J., McKenzie, D., Johnson, C.J., Aiken, J.M.
Background: Transmissible spongiform encephalopathies (TSEs) are a group of fatal neurodegenerative diseases caused by novel infectious agents referred to as prions. Prions appear to be composed primarily, if not exclusively, of a misfolded isoform of the cellular prion protein. TSE infectivity...
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Zebrafish Targeted Mutagenesis to Unveil Normal Physiological Functions of, and Interactions between, Prion Protein (PrP) and Amyloid Precursor Protein (APP): Relevance to Alzheimer’s disease
DownloadSpring 2017
Much of the work on Prion Protein (PrPC) and Amyloid Precursor Protein (APP) biology has focused on the contributions of their misfolded forms or aggregated metabolites to prion diseases and Alzheimer’s disease, respectively. As subversion/partial loss of some normal functions are also likely...