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Assessing the Feasibility of Learning Biomedical Phenotype Patterns Using High-Throughput Omics Profiles
DownloadSpring 2014
A decade after the completion of the human genome project, the rapid advancement of the high-throughput measurement technologies has made omics (genomics, epigenomics, transcriptomics, metabolomics) profiling feasible. The availability of such omics profiles has raised the hope for the...
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Fall 2012
Functional Magnetic Resonance Imaging (fMRI) measures the dynamic activity of each voxel of a brain. This dissertation addresses the challenge of learning a diagnostic classifier that uses a subject’s fMRI data to distinguish subjects with neuropsychiatric disorders from healthy controls. fMRI...
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Spring 2011
Standard survival analysis focuses on population-based studies. The objective of our work, survival prediction, is different: to find the most accurate model for predicting the survival times for each individual patient. We view this as a regression problem, where we try to map the features for...
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Machine learning for medical applications with limited data: Incorporating domain expertise and addressing domain-shift
DownloadFall 2022
Machine learning has the potential to help medical experts to deliver better healthcare. There are, however, important technical challenges that need to be solved before we can develop reliable models for clinical practice, including: (1) Limited number of labeled instances, (2) Uncertainty of...
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Fall 2013
Many learning situations involve learning the conditional distribution $p(y|x)$ when the training data is drawn from the training distribution $p{tr}(x)$, even though it will later be used to predict for instances drawn from a different test distribution $p{te}(x)$. Most current approaches focus...
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Spring 2018
Patients with Type I Diabetes (T1D) must take insulin injections to prevent the serious long term effects of hyperglycemia â high blood glucose (BG). These patients must also be careful not to inject too much insulin because this could induce hypoglycemia (low BG), which can be fatal. Patients...
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Spring 2021
This dissertation demonstrates how to utilize data collected previously from different sources to facilitate learning and inference for a target task. Learning from scratch for a target task or environment can be expensive and time-consuming. To address this problem, we make three contributions...