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Skip to Search Results- 1Alvarado, Laura
- 1Anderson, Sharon
- 1Anderson, Sharon D
- 1Arvanitidis, Anastasia P
- 1Auriat, Angela Michelle
- 1Bamford, Jeremy, Andrew
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Fall 2016
Background: Intracerebral Hemorrhage (ICH) is associated with high morbidity and patients commonly suffer motor dysfunction. ICH volume is a significant predictor of outcome, and perihematoma edema may also represent tissue injury. Diffusion Tensor Imaging (DTI) can be used to assess in-vivo...
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Fall 2009
Stroke is a leading cause of disability in Canada. Delayed hypothermia improves outcome in patients following cardiac arrest and reduces lesion volume in rodents after transient focal ischemia, but less is known about the effectiveness of delayed hypothermia following permanent focal ischemia. In...
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Development of Surrogate Spinal Cords for the Evaluation of Electrode Arrays Used in Intraspinal Implants
DownloadSpring 2012
A surrogate spinal cord was developed to test the mechanical stability of electrode arrays for intraspinal implants. The mechanical and surface properties of candidate materials were tested. The elastic modulus was characterized using dynamic mechanical analysis. Forces required to indent the...
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Spring 2012
Stroke, a reduction in blood flow to the brain, activates various proteins that contribute to neuronal death. The matrix metalloproteinases (MMPs), specifically MMP2 and MMP9, are important in maintaining the blood brain barrier (BBB). After a stroke the BBB permeability increases which is...
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Spring 2024
Intracerebral hemorrhage (ICH), a devastating stroke caused by the rupture of vasculature in the brain, is responsible for <20% of all strokes, yet accounts for a disproportionately high burden of stroke related death and disability. The formation and degradation of the hematoma (blood clot)...
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External sensors for the feedback control of functional electrical stimulation assisted walking
DownloadFall 2010
Functional electrical stimulation (FES) is a rehabilitative technology that can be used to improve walking in individuals with mobility impairments due to neurologic injury or disease. Feedback is essential for efficient FES-assisted walking. The overall goal of my project was to investigate...
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Hypothermia and the Evaluation of Combination Therapies for Neonatal Hypoxic-Ischemic Brain Damage
DownloadFall 2016
Hypoxic-ischemic brain damage (HIBD) is still of major concern in the neonatal period, resulting in chronic neurological sequelae stemming from damage to the term newborn brain. Full-body and focal-head cooling within 6 hours of birth have proven neuroprotective in human newborns and various...
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Influence of therapeutic hypothermia on neuroprotection and post-ischemic plasticity in a rat model of global ischemia
DownloadFall 2011
Blood flow to the brain may be disrupted by either a stroke (such as focal ischemia or hemorrhage) or cardiac arrest, where the whole brain becomes ischemic. Both forms of injury result in irreversible neuronal loss leading to neurological impairments and a decrease in the quality of life....
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Intracortical administration of pleiotrophin in ischemic stroke: investigating functional outcomes and glial expression
DownloadSpring 2023
Ischemic stroke is the leading cause of disability and third leading cause of death in Canada, exerting a serious burden on stroke survivors, their families, and healthcare resources. Characterized by brain damage due to loss of blood flow and oxygen supply, ischemic stroke is characterized by...
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Fall 2013
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke but the role of increased intracranial pressure (ICP) in ICH is unclear - especially since most studies measure ICP in rodents tethered or under anesthesia or restraint. Thus, ICP was measured using telemetry in untethered, awake...