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Development of Surrogate Spinal Cords for the Evaluation of Electrode Arrays Used in Intraspinal Implants

  • Author / Creator
    Cheng,Cheng
  • A surrogate spinal cord was developed to test the mechanical stability of electrode arrays for intraspinal implants. The mechanical and surface properties of candidate materials were tested. The elastic modulus was characterized using dynamic mechanical analysis. Forces required to indent the surrogate cords to specified depths was measured. Frictional forces were measured by pulling a needle out at a controlled rate. The results were compared to actual spinal cords, either to value from literature or ex vivo measurements. Surrogate cords with the most suitable properties (formaldehyde crosslinked gelatin, 12 wt% in water) were implanted with two types of intraspinal electrode arrays (one made of individual microwires and another of microwires anchored with a solid base), and an elongation was applied. Arrays with solid bases impeded the deformation of the cord suggesting that they could cause tissue damage in vivo, while arrays without a base moved freely with the cord.

  • Subjects / Keywords
  • Graduation date
    2012-06
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R3M60H
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Department of Chemical and Materials Engineering
  • Specialization
    • Materials Engineering
  • Supervisor / co-supervisor and their department(s)
    • Elias, Anastasia (Chemical and Materials Engineering)
  • Examining committee members and their departments
    • Elias, Anastasia (Chemical and Materials Engineering)
    • Nychka, John (Chemical and Materials Engineering)
    • Moussa, Walied (Mechanical Engineering)