Intracranial Pressure Changes in Rat Models of Intracerebral Hemorrhage

• Author / Creator

  Hiploylee, Carmen

• Intracerebral hemorrhage (ICH) is a devastating subtype of stroke but the role of increased intracranial pressure (ICP) in ICH is unclear - especially since most studies measure ICP in rodents tethered or under anesthesia or restraint. Thus, ICP was measured using telemetry in untethered, awake rats after ICH for 4 days. In PART 1, no pressure differences were found between the site of injury and epidural space. In PART 2, a severe ICH increased ICP for 4 days with modest reductions in cerebral perfusion pressure. In PART 3, moderate to severe ICHs were compared in different models of ICH. When ICH was induced by a collagenase infusion, ICP was increased for 2 days. However, ICP did not increase when the ICH was induced by a whole blood infusion. Lastly, increases in edema correlated with increases in ICP. These findings demonstrate ICH model differences that must be considered when evaluating therapies.

• Subjects / Keywords

  • Intracerebral Hemorrhage
  • Intracranial Pressure

• Graduation date

  Fall 2013

• Type of Item

  Thesis

• Degree

  Master of Science

• DOI

  https://doi.org/10.7939/R3707WX11

• License

  This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.