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Skip to Search Results- 2Kinnaird, Adam
- 2Parker, Christopher A. C.
- 1Abdulsalam Alharbi
- 1Aktary, Zackie M
- 1Akturk, Sait
- 1Alolayan, Waad Riyad
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Deciphering the mechanism(s) which limit reovirus spread in resistant lung and HNSCC cancer cells
DownloadFall 2016
Reovirus is a naturally benign virus that preferentially replicates in transformed cells and is currently undergoing clinical trials as a promising oncolytic therapy. In normal mouse fibroblasts, transformation by constitutively activated Ras oncogene is sufficient to promote reovirus infection....
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Decision Frequency Adaptation in Reinforcement Learning Using Continuous Options with Open-Loop Policies
DownloadFall 2023
In classic reinforcement learning(RL) for continuous control, agents make decisions at discrete and fixed time intervals. The duration between decisions becomes a crucial hyperparameter. Setting it too short may increase the problem’s difficulty by requiring the agent to make numerous decisions...
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Delivery of STAT3 inhibitor cucurbitacins to tumor by polymeric nano-carriers : Implications in cancer chemo- and immunotherapy
DownloadFall 2009
Signal Transducer and Activator of Transcription 3 (STAT3), a common oncogenic mediator, is constitutively activated in many types of human cancers and plays a critical role in tumor growth and cancer immune evasion. The focus of this dissertation is the delivery of STAT3 inhibitor cucurbitacins...
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Fall 2018
The adoption of powered myoelectric prostheses and their ability to improve quality of life for persons with amputations is hindered by the difficulty of controlling multiple degrees of freedom with a limited number of input signals. Different myoelectric control strategies have been developed to...
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Fall 2015
Understanding how an artificial agent may represent, acquire, update, and use large amounts of knowledge has long been an important research challenge in artificial intelligence. The quantity of knowledge, or knowing a lot, may be nicely thought of as making and updat- ing many predictions about...
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Fall 2013
The aim of this work is to develop an effective non-viral carrier and to identify suitable gene targets that would induce apoptosis specifically in lymphoma cells upon down-regulation with short interfering RNA (siRNA). Lymphoma is common in children and young adults, and although survival rate...
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Development of block copolymer based nanocarriers for the solubilization and delivery of valspodar
DownloadFall 2011
One of the major causes of failure in cancer chemotherapy is multidrug resistance (MDR), where cancer cells become resistant to different types of anticancer drugs. Over-expression of membrane efflux pumps like P-glycoprotein (P-gp), which recognizes different chemotherapeutic agents and...
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Development of Genetic Medicines for the Treatment and Prevention of Infectious Disease, Cancer, and Aging
DownloadSpring 2022
Gene therapy has potential to become the Holy Grail of modern medicine, however, its clinical success has been hindered due to the lack of a safe and effective nucleic acid delivery platform. The recent success of non-viral RNA delivery platforms has revitalized the field and spurred great...
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Development of Novel Polymeric Micellar DACHPt for Enhanced Platinum Based Chemotherapy in Colorectal Cancer
DownloadSpring 2019
One of the major limitations of chemotherapy in cancer treatment is the side effects of anti-cancer drugs. This happens due to non-selective distribution of most standard chemotherapies, and their action on cancer and all normal dividing cells. The objective of this project is to develop a novel...