Development of a non-viral delivery system for siRNA for treatment of lymphoma

• Author / Creator

  Sahin,B

• The aim of this work is to develop an effective non-viral carrier and to identify suitable gene targets that would induce apoptosis specifically in lymphoma cells upon down-regulation with short interfering RNA (siRNA). Lymphoma is common in children and young adults, and although survival rate is high, the short and long-term effects of conventional drug therapy constitute a major problem in patients’ adult life. The use of siRNA and polymer-based carriers as a treatment for cancer is hypothesized to reduce the negative effects of drug treatment while increasing the survival rate.

• Subjects / Keywords

  • Non-viral
  • Lymphoma
  • Silencing
  • PEI
  • Cancer
  • Polymeric carrier
  • Delivery
  • SiRNA

• Graduation date

  Fall 2013

• Type of Item

  Thesis

• Degree

  Master of Science

• DOI

  https://doi.org/10.7939/R3445HM6J

• License

  This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.