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- 4Cairo, Christopher W.
- 4Richards, Michele R
- 3Guo, Tianlin
- 3Hunter, Carmanah D
- 2Zou, Chunxia
- 1Darestani, Reza Rezaei
- 1glycolipid, sphingolipid, glycosphingolipid, organic synthesis, lipid probes, fluorescent probes
- 1glycoside hydrolase, neuraminidase, sialidase, inhibitor, medicinal chemistry
- 1glycoside hydrolase, neuraminidase, sialidase, viral, bacterial, human, molecular modeling, medicinal chemistry
- 1glycosyl hydrolase, neuraminidase, sialidase, enzyme kinetics, substrate specificity, Neu5Ac, Neu5Gc
Recognition of terminal sialic acids is central to many cellular processes, and structural modification of sialic acid can disrupt these interactions. A prominent, naturally occuring, modification of sialic acid is 9-O-acetylation (9-O-Ac). Study of this modification through generation and...
Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivityDownload
Inhibitors of viral neuraminidase enzymes have been previously developed as therapeutics. Humans can express multiple forms of neuraminidase enzymes (NEU1, NEU2, NEU3, NEU4) that share a similar active site and enzymatic mechanism with their viral counterparts. Using a panel of purified human...
Human neuraminidases (NEU) are associated with human diseases including cancer, atherosclerosis, and diabetes. To obtain small molecule inhibitors as research tools for the study of their biological functions, we designed a library of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues...
The plasma membrane of cells contains a diverse array of lipids that provide important structural and biological features. Glycolipids are typically a minor component of the cell membrane and consist primarily of glycosphingolipids (GSLs). GSLs in vertebrates contain a multifarious assortment of...