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- 4Cairo, Christopher W
- 4Richards, Michele R
- 3Guo, Tianlin
- 3Hunter, Carmanah D
- 2Zou, Chunxia
- 1Darestani, Reza Rezaei
- 1glycolipid, sphingolipid, glycosphingolipid, organic synthesis, lipid probes, fluorescent probes
- 1glycoside hydrolase, neuraminidase, sialidase, inhibitor, medicinal chemistry
- 1glycoside hydrolase, neuraminidase, sialidase, viral, bacterial, human, molecular modeling, medicinal chemistry
- 1glycosyl hydrolase, neuraminidase, sialidase, enzyme kinetics, substrate specificity, Neu5Ac, Neu5Gc
Human neuraminidase isoenzymes show variable activities for 9-O-acetyl-sialoside substratesDownload
Recognition of terminal sialic acids is central to many cellular processes, and structural modification of sialic acid can disrupt these interactions. A prominent, naturally occuring, modification of sialic acid is 9-O-acetylation (9-O-Ac). Study of this modification through generation and...
Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity
Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivityDownload
Inhibitors of viral neuraminidase enzymes have been previously developed as therapeutics. Humans can express multiple forms of neuraminidase enzymes (NEU1, NEU2, NEU3, NEU4) that share a similar active site and enzymatic mechanism with their viral counterparts. Using a panel of purified human...
Selective Inhibitors of Human Neuraminidase 3
Human neuraminidases (NEU) are associated with human diseases including cancer, atherosclerosis, and diabetes. To obtain small molecule inhibitors as research tools for the study of their biological functions, we designed a library of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues...
Synthetic strategies for modified glycosphingolipids and their design as probes
The plasma membrane of cells contains a diverse array of lipids that provide important structural and biological features. Glycolipids are typically a minor component of the cell membrane and consist primarily of glycosphingolipids (GSLs). GSLs in vertebrates contain a multifarious assortment of...