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- 5Cairo, Christopher W.
- 5Guo, Tianlin
- 3Richards, Michele R
- 2Hunter, Carmanah D
- 2Pshezhetsky, Alexey V
- 2Zou, Chunxia
- 1cell migration
- 1glycolipid, sphingolipid, glycosphingolipid, organic synthesis, lipid probes, fluorescent probes
- 1glycoside hydrolase, neuraminidase, sialidase, NEU3, medicinal chemistry, inhibitor
- 1glycoside hydrolase, neuraminidase, sialidase, inhibitor, medicinal chemistry
- 1glycoside hydrolase, neuraminidase, sialidase, viral, bacterial, human, molecular modeling, medicinal chemistry
The human neuraminidase enzymes (NEU1, NEU2, NEU3, and NEU4) are a class of enzymes implicated in pathologies including cancer and diabetes. Several reports have linked neuraminidase activity to the regulation of cell migration in cancer cells. Using an in vitro cell migration assay on...
Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivityDownload
Inhibitors of viral neuraminidase enzymes have been previously developed as therapeutics. Humans can express multiple forms of neuraminidase enzymes (NEU1, NEU2, NEU3, NEU4) that share a similar active site and enzymatic mechanism with their viral counterparts. Using a panel of purified human...
Human neuraminidases (NEU) are associated with human diseases including cancer, atherosclerosis, and diabetes. To obtain small molecule inhibitors as research tools for the study of their biological functions, we designed a library of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues...
Inhibitors of human neuraminidase enzymes (NEU) are recognized as important tools for the study of the biological functions of NEU and will be potent tools for elucidating the role of these enzymes in regulating the repertoire of cellular glycans. Here we report the discovery of selective...
The plasma membrane of cells contains a diverse array of lipids that provide important structural and biological features. Glycolipids are typically a minor component of the cell membrane and consist primarily of glycosphingolipids (GSLs). GSLs in vertebrates contain a multifarious assortment of...