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Skip to Search Results- 8Plastow, Graham
- 2Dekkers, Jack C. M.
- 2Kemp, Robert A.
- 2Ladinig, Andrea
- 2Lunney, Joan K.
- 2Wang, Zhiquan
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A genome-wide association study of fetal response to type 2 porcine reproductive and respiratory syndrome virus challenge
Download2016-02-05
Plastow, Graham, Ladinig, Andrea, Harding, John, Wang, Zhiquan, Wilkinson, James, Yang, Tianfu
Control of porcine reproductive and respiratory syndrome (PRRS) is economically important for the swine industry worldwide. As current PRRS vaccines do not completely protect against heterologous challenge, alternative means of control, including enhanced genetic resilience, are needed. For...
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Comparative transcriptomic analysis of rectal tissue from beef steers revealed reduced host immunity in Escherichia coli O157:H7 super-shedders
Download2016-03-09
McAllister, Tim A., Wang, Ou, Plastow, Graham, Stanford, Kim, Liang, Guanxiang, Guan, Le L., Selinger, Brent
Super-shedder cattle are a major disseminator of E. coli O157:H7 into the environment, and the terminal rectum has been proposed as the primary E. coli O157:H7 colonization site. This study aimed to identify host factors that are associated with the super-shedding process by comparing...
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Discovery of Predictors of Mycoplasma hyopneumoniae Vaccine Response Efficiency in Pigs: 16S rRNA Gene Fecal Microbiota Analysis
Download2020-07-22
Munyaka, Peris M., Blanc, Fany, Estelle, Jordi, Lemonnier, Gaetan, Leplat, Jean-Jacques, Rossignol, Marie-Noelle, Jardet, Deborah, Plastow, Graham, Billon, Yvon, Willing, Benjamin P., Rogel-Gaillard, Claire
The gut microbiota comprises a large and diverse community of bacteria that play a significant role in swine health. Indeed, there is a tight association between the enteric immune system and the overall composition and richness of the microbiota, which is key in the induction, training and...
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Genetic and genomic basis of antibody response to porcine reproductive and respiratory syndrome (PRRS) in gilts and sows
Download2016-01-01
Serao, Nick V. L., Kemp, Robert A., Mote, Benny E., Willson, Philip, Harding, John C. S., Bishop, Stephen C., Plastow, Graham S., Dekkers, Jack C. M.
Background:Our recent research showed that antibody response to porcine reproductive and respiratory syn-drome (PRRS), measured as sample-to-positive (S/P) ratio, is highly heritable and has a high genetic correlation with reproductive performance during a PRRS outbreak. Two major quantitative...
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Genome wide association studies (GWAS) identify QTL on SSC2 and SSC17 affecting loin peak shear force in crossbred commercial pigs
Download2016-02-22
Miar, Younes, Wang, Zhiquan, Kemp, Robert A., Boddicker, Nicholas, Yang, Tianfu, Plastow, Graham, Zhang, Chunyan, Charagu, Patrick, Bruce, Heather
Of all the meat quality traits, tenderness is considered the most important with regard to eating quality and market value. In this study we have utilised genome wide association studies (GWAS) for peak shear force (PSF) of loin muscle as a measure of tenderness for 1,976 crossbred commercial...
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Genomic Prediction of Piglet Responses to Infection with One or Two Porcine Reproductive and Respiratory Syndrome Virus Isolates
Download2018-01-01
Waide, Emily H., Tuggle, Christopher K., Serao, Nick V. I., Schroyen, Martine, Hess, Andrew, Rowland, Raymond R. R., Lunney, Joan K., Plastow, Graham, Dekkers, Jack C. M.
Genomic prediction of the pig’s response to the porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) would be a useful tool in the swine industry. This study investigated the accuracy of genomic prediction based on porcine SNP60 Beadchip data using training and validation datasets...
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Kinome profiling of peripheral blood mononuclear cells collected prior to vaccination reveals biomarkers and potential mechanisms of vaccine unresponsiveness in pigs
Download2020-12-01
Lipsit, Sean W. L., Wilkinson, James, Scruten, Erin, Facciuolo, Antonio, Denomy, Connor, Griebel, Philip J., Kusalik, Anthony, Plastow, Graham, Napper, Scott
Inter-individual variance in host immune responses following vaccination can result in failure to develop protective immunity leaving individuals at risk for infection in addition to compromising herd immunity. While developing more efficacious vaccines is one strategy to mitigate this problem,...
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Maternal and fetal predictors of fetal viral load and death in third trimester, type 2 porcine reproductive and respiratory syndrome virus infected pregnant gilts
Download2015-09-25
Wilkinson, Jamie M., Lunney, Joan K., Detmer, Susan E., Ladinig, Andrea, Harding, John C.S., Ashley, Carolyn, Plastow, Graham
Minimal research has focused on understanding mechanisms underlying porcine reproductive and respiratory syndrome virus (PRRSV) induced reproductive failure. We have completed a large-scale project investigating phenotypic and genotypic predictors of reproductive PRRS severity in which numerous...
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Neonatal Exposure to Amoxicillin Alters Long-Term Immune Response Despite Transient Effects on Gut-Microbiota in Piglets
Download2019-01-01
Fouhse, Janelle M., Yang, Kaiyuan, More-Bayona, Juan, Gao, Yanhua, Goruk, Susan, Plastow, Graham, Field, Catherine J., Barreda, Daniel R., Willing, Benjamin P.
Antibiotic exposure during neonatal development may result in transient or persistent alterations of key microbes that are vital for normal development of local and systemic immunity, potentially impairing immune competence later in life. To further elucidate the relationship between antibiotic...