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Skip to Search Results- 118Chemical and Materials Engineering, Department of
- 113Chemical and Materials Engineering, Department of/Research Articles and Materials (Chemical and Materials Engineering)
- 8Surgery, Department of
- 8Surgery, Department of/Orthopaedic Surgery
- 5Chemical and Materials Engineering, Department of/Process Systems Engineering
- 3Human Ecology, Department of
- 14Rapid Solidification
- 12Impulse Atomization
- 11Undercooling
- 8Cryopreservation
- 7Atomization
- 7Microstructure
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Investigating cryoinjury using simulations and experiments: 2. TF-1 cells during graded freezing (interrupted slow cooling without hold time)
Download2014-09-22
McGann, L.E., Ross-Rodriguez, L.U., Elliott, J.A.
Cryopreservation plays a key role in the long-term storage of native and engineered cells and tissues for research and clinical applications. The survival of cells and tissues after freezing and thawing depends on the ability of the cells to withstand a variety of stresses imposed by the...
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Study of electrical conductivity response upon formation of ice and gas hydrates from salt solutions by a second generation high pressure electrical conductivity probe
Download2014-11-01
Sowa, Barbara, Zhang, Xuehua, Kozielski, Karen A., Dunstan, Dave E., Hartley, Patrick G., Maeda, Nobuo
We recently reported the development of a high pressure electrical conductivity probe (HP-ECP) for experimental studies of formation of gas hydrates from electrolytes. The onset of the formation of methane-propane mixed gas hydrate from salt solutions was marked by a temporary upward spike in the...
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2014-10-08
McGann, L.E., Elliott, J.A., Law, G.K., Abazari, A., Jomha, N.M.
Some minor errors in our published manuscript need to be addressed
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Investigating cryoinjury using simulations and experiments: 1. TF-1 cells during two-step freezing (rapid cooling interrupted with a hold time)
Download2014-09-22
McGann, L. E., Ross-Rodriguez, L. U., Elliott, J. A.
There is significant interest in designing a cryopreservation protocol for hematopoietic stem cells (HSC) which does not rely on dimethyl sulfoxide (Me2SO) as a cryoprotectant. Computer simulations that describe cellular osmotic responses during cooling and warming can be used to optimize the...
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Characterization of cryobiological responses in TF-1 cells using interrupted freezing procedures
Download2014-09-22
McGann, L. E., Elliott, J. A., Ross-Rodriguez, L. U.
Cryopreservation currently is the only method for long-term preservation of cellular viability and function for uses in cellular therapies. Characterizing the cryobiological response of a cell type is essential in the approach to designing and optimizing cryopreservation protocols. For cells used...
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2014/22/2014
Prickett, R. C., McGann, L. E., Elliott, J. A., Hakda, S.
A non-ideal osmotic equilibrium equation is proposed as a replacement for the Boyle van’t Hoff equation to describe the equilibrium volume of a living cell as a function of external osmolality. Contrary to common understanding, the Boyle van’t Hoff equation is only valid for ideal, dilute...
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2014
Prasad, V., Laouar, L., Jomha, N. M., McGann, L. E., Fahmy, M. D., Almansoori, K. A., Elliott, J. A.
Vitrification of articular cartilage (AC) could enhance tissue availability but requires high concentrations of cyroprotective agents (CPAs). This study investigated relative injuries caused by commonly used CPAs. We hypothesized that the in situ chondrocyte dose–injury relationships of five...
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2014-09-26
Rekieh, K., Abazari, A., Elliott, J.A., Jomha, N.M., Law, G.K., McGann, L.E.
Objective: Osteochondral allografting is an effective method to treat large osteochondral defects but difficulties in tissue preservation have significantly limited the application of this technique. Successful cryopreservation of articular cartilage (AC) could improve the clinical availability...
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2013
Yu, H., Jomha, N. M., Elliott, J. A., Al-Abbasi, K. K., McGann, L. E.
In previous research, we successfully cryopreserved intact human articular cartilage on its bone base with high chondrocyte viability using a vitrification protocol that entailed sequential exposure to several cryopreserving agents (CPAs) at lowering temperatures resulting in a high final...
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2012
Elliott, J. A., Zhou, X., McGann, L. E., Adesida, A. B., Abazari, A., Law, G. K., Laouar, L., Forbes, J. F., Jomha, N. M., Maghdoori, B.
Articular cartilage injuries do not heal and large defects result in osteoarthritis with major personal and socioeconomic costs. Osteochondral transplantation is an effective treatment for large joint defects but its use is limited by the inability to store cartilage for long periods of time....